@article{oai:repo.qst.go.jp:00046424,
 author = {Hirobe, Tomohisa and Wakamatsu, Kazumasa and Ito, Shosuke and 廣部 知久},
 issue = {10},
 journal = {Zoological Science},
 month = {Oct},
 note = {We previously demonstrated that a novel mutation, characterized by light-colored coats and ruby eyes, which occurred spontaneously in mice in our laboratory, exhibited deletion in the Hps5 gene (ru2d/Hps5ru2-d). To clarify the mechanism of this hypopigmentation, the characteristics of the neonatal development of ru2d/ru2d melanocytes were investigated in detail with special reference to those of +/+ melanocytes. In ru2d/ru2d mice, there were fewer epidermal melanocytes than in +/+ mice, whereas there was no difference in the numbers of epidermal melanoblasts in +/+ and ru2d/ru2d mice, both in dorsal and ventral skins. Epidermal melanocytes with increased dopa-melanin deposition and dendritogenesis were greatly increased by injecting L-Tyr subcutaneously into newborn ru2d/ru2d mice. The eumelanin content in the epidermis and dermis in postnatal ru2d/ru2d mice was much lower than in +/+ mice, whereas similar pheomelanin content was observed 5.5 or 7.5 days after birth both in dorsal and ventral skins. Moreover, the eumelanin content in the dorsal and ventral hairs in 5-week-old ru2d/ru2d mice was much lower than in +/+ mice, whereas pheomelanin content were two to four times greater than in +/+ mice. These results suggest that the ru2d allele suppresses the differentiation of melanocytes through the inhibition of eumelanin synthesis, but stimulates pheomelanin synthesis in melanocytes.},
 pages = {652--661},
 title = {A New Mutation of Mouse Ruby-eye 2, ru2d/Hps5ru2-d Inhibits Eumelanin Synthesis but Stimulates Pheomelanin Synthesis in Melanocytes},
 volume = {29},
 year = {2012}
}