{"created":"2023-05-15T14:36:04.138059+00:00","id":46424,"links":{},"metadata":{"_buckets":{"deposit":"47a9f352-39a1-4505-958c-5a74a6c683ec"},"_deposit":{"created_by":1,"id":"46424","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46424"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046424","sets":["1"]},"author_link":["462453","462452","462451","462454"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"661","bibliographicPageStart":"652","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Zoological Science"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We previously demonstrated that a novel mutation, characterized by light-colored coats and ruby eyes, which occurred spontaneously in mice in our laboratory, exhibited deletion in the Hps5 gene (ru2d/Hps5ru2-d). To clarify the mechanism of this hypopigmentation, the characteristics of the neonatal development of ru2d/ru2d melanocytes were investigated in detail with special reference to those of +/+ melanocytes. In ru2d/ru2d mice, there were fewer epidermal melanocytes than in +/+ mice, whereas there was no difference in the numbers of epidermal melanoblasts in +/+ and ru2d/ru2d mice, both in dorsal and ventral skins. Epidermal melanocytes with increased dopa-melanin deposition and dendritogenesis were greatly increased by injecting L-Tyr subcutaneously into newborn ru2d/ru2d mice. The eumelanin content in the epidermis and dermis in postnatal ru2d/ru2d mice was much lower than in +/+ mice, whereas similar pheomelanin content was observed 5.5 or 7.5 days after birth both in dorsal and ventral skins. Moreover, the eumelanin content in the dorsal and ventral hairs in 5-week-old ru2d/ru2d mice was much lower than in +/+ mice, whereas pheomelanin content were two to four times greater than in +/+ mice. These results suggest that the ru2d allele suppresses the differentiation of melanocytes through the inhibition of eumelanin synthesis, but stimulates pheomelanin synthesis in melanocytes.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0289-0003","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirobe, Tomohisa"}],"nameIdentifiers":[{"nameIdentifier":"462451","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakamatsu, Kazumasa"}],"nameIdentifiers":[{"nameIdentifier":"462452","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Shosuke"}],"nameIdentifiers":[{"nameIdentifier":"462453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"廣部 知久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"462454","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A New Mutation of Mouse Ruby-eye 2, ru2d/Hps5ru2-d Inhibits Eumelanin Synthesis but Stimulates Pheomelanin Synthesis in Melanocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A New Mutation of Mouse Ruby-eye 2, ru2d/Hps5ru2-d Inhibits Eumelanin Synthesis but Stimulates Pheomelanin Synthesis in Melanocytes"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-12"},"publish_date":"2012-10-12","publish_status":"0","recid":"46424","relation_version_is_last":true,"title":["A New Mutation of Mouse Ruby-eye 2, ru2d/Hps5ru2-d Inhibits Eumelanin Synthesis but Stimulates Pheomelanin Synthesis in Melanocytes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:51:59.618679+00:00"}