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Neural Crest Cells Retain Their Capability for Multipotential Differentiation Even After Lineage-Restricted Stages
https://repo.qst.go.jp/records/46120
https://repo.qst.go.jp/records/461200b3d802e-7f63-489a-8c82-a37e7fca2689
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-07-01 | |||||
| タイトル | ||||||
| タイトル | Neural Crest Cells Retain Their Capability for Multipotential Differentiation Even After Lineage-Restricted Stages | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Motohashi, Tsutomu
× Motohashi, Tsutomu× Yamanaka, Katsumasa× Chiba, Kairi× Miyajima, Kentaro× Aoki, Hitomi× Hirobe, Tomohisa× Kunisada, Takahiro× 廣部 知久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Multipotency of neural crest cells (NC cells) is thought to be a transient phase at the early stage of their generation; after NC cells emerge from the neural tube, they are specified into the lineage-restricted precursors. We analyzed the differentiation of early-stage NC-like cells derived from Sox10-IRES-Venus ES cells, where the expression of Sox10 can be visualized with a fluorescent protein. Unexpectedly, both the Sox101/Kit2 cells and the Sox101/Kit1 cells, which were restricted in vivo to the neuron (N)-glial cell (G) lineage and melanocyte (M) lineage, respectively, generated N, G, and M, showing that they retain multipotency. We generated mice from the Sox10-IRES-Venus ES cells and analyzed the differentiation of their NC cells. Both the Sox101/Kit2 cells and Sox101/Kit1 cells isolated from these mice formed colonies containing N, G, and M, showing that they are also multipotent. These findings suggest that NC cells retain multipotency even after the initial lineage-restricted stages. |
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| 書誌情報 |
Developmental Dynamics 巻 240, 号 7, p. 1681-1693, 発行日 2011-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1058-8388 | |||||
