{"created":"2023-05-15T14:35:50.829241+00:00","id":46120,"links":{},"metadata":{"_buckets":{"deposit":"aa749f35-2a6e-4ee3-b5e4-1d21852c3fdb"},"_deposit":{"created_by":1,"id":"46120","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46120"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046120","sets":["1"]},"author_link":["459152","459153","459154","459149","459156","459151","459150","459155"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"1693","bibliographicPageStart":"1681","bibliographicVolumeNumber":"240","bibliographic_titles":[{"bibliographic_title":"Developmental Dynamics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Multipotency of neural crest cells (NC cells) is thought to be a transient phase at the early stage of their\ngeneration; after NC cells emerge from the neural tube, they are specified into the lineage-restricted precursors.\nWe analyzed the differentiation of early-stage NC-like cells derived from Sox10-IRES-Venus ES\ncells, where the expression of Sox10 can be visualized with a fluorescent protein. Unexpectedly, both the\nSox101/Kit2 cells and the Sox101/Kit1 cells, which were restricted in vivo to the neuron (N)-glial cell (G)\nlineage and melanocyte (M) lineage, respectively, generated N, G, and M, showing that they retain multipotency.\nWe generated mice from the Sox10-IRES-Venus ES cells and analyzed the differentiation of their\nNC cells. Both the Sox101/Kit2 cells and Sox101/Kit1 cells isolated from these mice formed colonies\ncontaining N, G, and M, showing that they are also multipotent. These findings suggest that NC cells\nretain multipotency even after the initial lineage-restricted stages.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1058-8388","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Motohashi, Tsutomu"}],"nameIdentifiers":[{"nameIdentifier":"459149","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamanaka, Katsumasa"}],"nameIdentifiers":[{"nameIdentifier":"459150","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chiba, Kairi"}],"nameIdentifiers":[{"nameIdentifier":"459151","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyajima, Kentaro"}],"nameIdentifiers":[{"nameIdentifier":"459152","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Hitomi"}],"nameIdentifiers":[{"nameIdentifier":"459153","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirobe, Tomohisa"}],"nameIdentifiers":[{"nameIdentifier":"459154","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kunisada, Takahiro"}],"nameIdentifiers":[{"nameIdentifier":"459155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"廣部 知久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459156","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neural Crest Cells Retain Their Capability for Multipotential Differentiation Even After Lineage-Restricted Stages","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neural Crest Cells Retain Their Capability for Multipotential Differentiation Even After Lineage-Restricted Stages"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-01"},"publish_date":"2011-07-01","publish_status":"0","recid":"46120","relation_version_is_last":true,"title":["Neural Crest Cells Retain Their Capability for Multipotential Differentiation Even After Lineage-Restricted Stages"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:55:37.602619+00:00"}