{"_buckets": {"deposit": "cdadfb8c-c58c-4ab7-86ed-446bcf879b0d"}, "_deposit": {"created_by": 1, "id": "46090", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "46090"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00046090", "sets": ["1"]}, "author_link": ["458839", "458840", "458843", "458834", "458835", "458845", "458841", "458836", "458842", "458837", "458844", "458846", "458838", "458833"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "292", "bibliographicPageStart": "287", "bibliographicVolumeNumber": "52", "bibliographic_titles": [{"bibliographic_title": "Journal of Radiation Research"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Adhesion of inflammatory cells to endothelial cells is regarded to be involved in the process of radiation-induced damage and fibrosis.  Intercellular adhesion molecule-1 (ICAM-1) and transforming growth factor-beta1 (TGF-B1) are suggested to play important roles in this process.  In this study, radiation-induced ICAM-1 expression was investigated with the use of an inhibitor of TGF-B1 receptor kinase (SB431542) and compared between the effects of X-ray and carbon-ion beam.  Cell cultures of human umbilical vein endothelial cells (HUVE cells) were incubated with TGF-B1 and irradiated with 140 KV X-ray.  Next, HUVE cells were irradiated with X-ray and 220 MeV carbon-ion beam with or without SB431542.  Immunofluorescence analysis was used to quantify ICAM-1 expression.  The expression of ICAM-1 in HUVE cells was significantly increased by the stimulation with TGF-B1.  Expression of ICAM-1 was increased by X-ray and carbon-ion beam irradiation and decreased significantly with SB431542 after both irradiations.  The expression of ICAM-1 increased by 2 Gy of carbon-ion beam irradiation was 6.7 fold higher than that of non-irradiated cells, while 5 Gy of X-ray irradiation increased the expression of ICAM-1 by 2.5 fold.  According to the ICAM-1 expression, the effect of carbon-ion beam was about 2.2, 4.4 and 5.0 times greater than that of the same doses of X-ray irradiation (1, 2 and 5 Gy, respectively). The present results suggested that radiation-induced ICAM-1 expression on HUVE cells was, at least partially, regulated by TGF-B1.  Carbon-ion beam induced significantly higher ICAM-1 expression than X-ray.", "subitem_description_type": "Abstract"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1269/jrr.10061", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://www.jstage.jst.go.jp/article/jrr/52/3/52_287/_article"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.jstage.jst.go.jp/article/jrr/52/3/52_287/_article", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0449-3060", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kiyohara, Hiroki"}], "nameIdentifiers": [{"nameIdentifier": "458833", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishizaki, Yasuki"}], "nameIdentifiers": [{"nameIdentifier": "458834", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Yoshiyuki"}], "nameIdentifiers": [{"nameIdentifier": "458835", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "458836", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hamada, Nobuyuki"}], "nameIdentifiers": [{"nameIdentifier": "458837", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohno, Tatsuya"}], "nameIdentifiers": [{"nameIdentifier": "458838", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Takeo"}], "nameIdentifiers": [{"nameIdentifier": "458839", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Yasuhiko"}], "nameIdentifiers": [{"nameIdentifier": "458840", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakano, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "458841", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "清原 浩樹", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "458842", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木 義行", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "458843", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "加藤 弘之", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "458844", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "大野 達也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "458845", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高橋 健夫", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "458846", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Radiation-induced ICAM-1 Expression via TGF-B1 Pathway on Human Umbilical Vein Endothelial Cells; Comparison between X-ray and Carbon-ion Beam Irradiation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Radiation-induced ICAM-1 Expression via TGF-B1 Pathway on Human Umbilical Vein Endothelial Cells; Comparison between X-ray and Carbon-ion Beam Irradiation"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46090", "pubdate": {"attribute_name": "公開日", "attribute_value": "2011-06-03"}, "publish_date": "2011-06-03", "publish_status": "0", "recid": "46090", "relation": {}, "relation_version_is_last": true, "title": ["Radiation-induced ICAM-1 Expression via TGF-B1 Pathway on Human Umbilical Vein Endothelial Cells; Comparison between X-ray and Carbon-ion Beam Irradiation"], "weko_shared_id": -1}