{"created":"2023-05-15T14:35:49.540285+00:00","id":46090,"links":{},"metadata":{"_buckets":{"deposit":"cdadfb8c-c58c-4ab7-86ed-446bcf879b0d"},"_deposit":{"created_by":1,"id":"46090","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46090"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046090","sets":["1"]},"author_link":["458839","458840","458843","458834","458835","458845","458841","458836","458842","458837","458844","458846","458838","458833"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"292","bibliographicPageStart":"287","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adhesion of inflammatory cells to endothelial cells is regarded to be involved in the process of radiation-induced damage and fibrosis.  Intercellular adhesion molecule-1 (ICAM-1) and transforming growth factor-beta1 (TGF-B1) are suggested to play important roles in this process.  In this study, radiation-induced ICAM-1 expression was investigated with the use of an inhibitor of TGF-B1 receptor kinase (SB431542) and compared between the effects of X-ray and carbon-ion beam.  Cell cultures of human umbilical vein endothelial cells (HUVE cells) were incubated with TGF-B1 and irradiated with 140 KV X-ray.  Next, HUVE cells were irradiated with X-ray and 220 MeV carbon-ion beam with or without SB431542.  Immunofluorescence analysis was used to quantify ICAM-1 expression.  The expression of ICAM-1 in HUVE cells was significantly increased by the stimulation with TGF-B1.  Expression of ICAM-1 was increased by X-ray and carbon-ion beam irradiation and decreased significantly with SB431542 after both irradiations.  The expression of ICAM-1 increased by 2 Gy of carbon-ion beam irradiation was 6.7 fold higher than that of non-irradiated cells, while 5 Gy of X-ray irradiation increased the expression of ICAM-1 by 2.5 fold.  According to the ICAM-1 expression, the effect of carbon-ion beam was about 2.2, 4.4 and 5.0 times greater than that of the same doses of X-ray irradiation (1, 2 and 5 Gy, respectively). The present results suggested that radiation-induced ICAM-1 expression on HUVE cells was, at least partially, regulated by TGF-B1.  Carbon-ion beam induced significantly higher ICAM-1 expression than X-ray.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1269/jrr.10061","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.jstage.jst.go.jp/article/jrr/52/3/52_287/_article"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jstage.jst.go.jp/article/jrr/52/3/52_287/_article","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0449-3060","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kiyohara, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"458833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishizaki, Yasuki"}],"nameIdentifiers":[{"nameIdentifier":"458834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Yoshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"458835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"458836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hamada, Nobuyuki"}],"nameIdentifiers":[{"nameIdentifier":"458837","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohno, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"458838","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Takeo"}],"nameIdentifiers":[{"nameIdentifier":"458839","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Yasuhiko"}],"nameIdentifiers":[{"nameIdentifier":"458840","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"458841","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清原 浩樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458842","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 義行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458843","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 弘之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458844","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大野 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458845","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 健夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458846","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Radiation-induced ICAM-1 Expression via TGF-B1 Pathway on Human Umbilical Vein Endothelial Cells; Comparison between X-ray and Carbon-ion Beam Irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radiation-induced ICAM-1 Expression via TGF-B1 Pathway on Human Umbilical Vein Endothelial Cells; Comparison between X-ray and Carbon-ion Beam Irradiation"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-06-03"},"publish_date":"2011-06-03","publish_status":"0","recid":"46090","relation_version_is_last":true,"title":["Radiation-induced ICAM-1 Expression via TGF-B1 Pathway on Human Umbilical Vein Endothelial Cells; Comparison between X-ray and Carbon-ion Beam Irradiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:55:59.234010+00:00"}