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Gene expression profiles in mouse liver after long-term low-dose-rate irradiation with gamma rays.
https://repo.qst.go.jp/records/46062
https://repo.qst.go.jp/records/4606209429978-55aa-4542-94d9-11c78c267600
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-05-23 | |||||
| タイトル | ||||||
| タイトル | Gene expression profiles in mouse liver after long-term low-dose-rate irradiation with gamma rays. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Uehara, Yosihiko
× Uehara, Yosihiko× Taki, Keiko× Nenoi, Mitsuru× Ichinohe, Kazuaki× Oghiso, Yoichi× Ono, Tetsuya× et.al× 上原 芳彦× 瀧 景子× 根井 充× 一戸 一晃× 小木曽 洋一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Changes in gene expression profiles in mouse liver induced by long-term low-dose-rate gamma irradiation were examined by microarray analysis. Three groups of male C57BL/6J mice were exposed to whole-body radiation at dose rates of 17–20 mGy/day, 0.86–1.0 mGy/day or 0.042–0.050 mGy/day for 401–485 days with cumulative doses of approximately 8 Gy, 0.4 Gy or 0.02 Gy, respectively. The gene expression levels in the livers of six animals from each exposure group were compared individually with that of pooled sham-irradiated animals. Some genes revealed a large variation in expression levels among individuals within each group, and the number of genes showing common changes in individuals from each group was limited: 20 and 11 genes showed more than 1.5-fold modulation with 17–20 mGy/day and 0.86–1.0 mGy/day, respectively. Three genes showed more than 1.5-fold modulation even at the lowest dose-rate of 0.04–0.05 mGy/day. Most of these genes were down-regulated. RT-PCR analysis confirmed the expression profiles of the majority of these genes. The results indicate that a few genes are modulated in response to very low-dose-rate irradiation. The functional analysis suggests that these genes may influence many processes, including obesity and tumorigenesis. | |||||
| 書誌情報 |
Radiation Research 巻 １７４, 号 ５, p. ６１１-６１７, 発行日 2010-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.rrjournal.org/doi/full/10.1667/RR2195.1 | |||||
| 関連名称 | http://www.rrjournal.org/doi/full/10.1667/RR2195.1 | |||||
