{"created":"2023-05-15T14:35:48.318873+00:00","id":46062,"links":{},"metadata":{"_buckets":{"deposit":"3d7e213f-4b63-44c4-8510-f098b7fe94bb"},"_deposit":{"created_by":1,"id":"46062","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46062"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046062","sets":["1"]},"author_link":["458507","458508","458509","458512","458514","458515","458510","458511","458517","458513","458518","458516"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"５","bibliographicPageEnd":"６１７","bibliographicPageStart":"６１１","bibliographicVolumeNumber":"１７４","bibliographic_titles":[{"bibliographic_title":"Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Changes in gene expression profiles in mouse liver induced by long-term low-dose-rate gamma irradiation were examined by microarray analysis. Three groups of male C57BL/6J mice were exposed to whole-body radiation at dose rates of 17–20 mGy/day, 0.86–1.0 mGy/day or 0.042–0.050 mGy/day for 401–485 days with cumulative doses of approximately 8 Gy, 0.4 Gy or 0.02 Gy, respectively. The gene expression levels in the livers of six animals from each exposure group were compared individually with that of pooled sham-irradiated animals. Some genes revealed a large variation in expression levels among individuals within each group, and the number of genes showing common changes in individuals from each group was limited: 20 and 11 genes showed more than 1.5-fold modulation with 17–20 mGy/day and 0.86–1.0 mGy/day, respectively. Three genes showed more than 1.5-fold modulation even at the lowest dose-rate of 0.04–0.05 mGy/day. Most of these genes were down-regulated. RT-PCR analysis confirmed the expression profiles of the majority of these genes. The results indicate that a few genes are modulated in response to very low-dose-rate irradiation. The functional analysis suggests that these genes may influence many processes, including obesity and tumorigenesis.","subitem_description_type":"Abstract"}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.rrjournal.org/doi/full/10.1667/RR2195.1"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.rrjournal.org/doi/full/10.1667/RR2195.1","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0033-7587","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Uehara, Yosihiko"}],"nameIdentifiers":[{"nameIdentifier":"458507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taki, Keiko"}],"nameIdentifiers":[{"nameIdentifier":"458508","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nenoi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"458509","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichinohe, Kazuaki"}],"nameIdentifiers":[{"nameIdentifier":"458510","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oghiso, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"458511","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"458512","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"458513","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上原 芳彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458514","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"瀧 景子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458516","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"一戸 一晃","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458517","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小木曽 洋一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458518","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Gene expression profiles in mouse liver after long-term low-dose-rate irradiation with gamma rays.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Gene expression profiles in mouse liver after long-term low-dose-rate irradiation with gamma rays."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-05-23"},"publish_date":"2011-05-23","publish_status":"0","recid":"46062","relation_version_is_last":true,"title":["Gene expression profiles in mouse liver after long-term low-dose-rate irradiation with gamma rays."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:56:19.077012+00:00"}