@article{oai:repo.qst.go.jp:00046062,
 author = {Uehara, Yosihiko and Taki, Keiko and Nenoi, Mitsuru and Ichinohe, Kazuaki and Oghiso, Yoichi and Ono, Tetsuya and et.al and 上原 芳彦 and 瀧 景子 and 根井 充 and 一戸 一晃 and 小木曽 洋一},
 issue = {５},
 journal = {Radiation Research},
 month = {Aug},
 note = {Changes in gene expression profiles in mouse liver induced by long-term low-dose-rate gamma irradiation were examined by microarray analysis. Three groups of male C57BL/6J mice were exposed to whole-body radiation at dose rates of 17–20 mGy/day, 0.86–1.0 mGy/day or 0.042–0.050 mGy/day for 401–485 days with cumulative doses of approximately 8 Gy, 0.4 Gy or 0.02 Gy, respectively. The gene expression levels in the livers of six animals from each exposure group were compared individually with that of pooled sham-irradiated animals. Some genes revealed a large variation in expression levels among individuals within each group, and the number of genes showing common changes in individuals from each group was limited: 20 and 11 genes showed more than 1.5-fold modulation with 17–20 mGy/day and 0.86–1.0 mGy/day, respectively. Three genes showed more than 1.5-fold modulation even at the lowest dose-rate of 0.04–0.05 mGy/day. Most of these genes were down-regulated. RT-PCR analysis confirmed the expression profiles of the majority of these genes. The results indicate that a few genes are modulated in response to very low-dose-rate irradiation. The functional analysis suggests that these genes may influence many processes, including obesity and tumorigenesis.},
 pages = {６１１--６１７},
 title = {Gene expression profiles in mouse liver after long-term low-dose-rate irradiation with gamma rays.},
 volume = {１７４},
 year = {2010}
}