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Evaluation of ferritin-overexpressing brain in newly developed transgenic mice
https://repo.qst.go.jp/records/46010
https://repo.qst.go.jp/records/4601003680b75-fdd2-4d1a-9ea8-9f88445316db
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-03-01 | |||||
| タイトル | ||||||
| タイトル | Evaluation of ferritin-overexpressing brain in newly developed transgenic mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hasegawa, Sumitaka
× Hasegawa, Sumitaka× Saito, Shigeyoshi× Takanashi, Junichi× Morokoshi, Yukie× Furukawa, Takako× Saga, Tsuneo× Aoki, Ichio× 長谷川 純崇× 齋藤 茂芳× 高梨 潤一× 諸越 幸恵× 古川 高子× 佐賀 恒夫× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aberrant expression of ferritin, a major iron-binding protein, has shown to be involved in neurodegenerative diseases. In this study, we generated transgenic (Tg) mice of human ferritin heavy chain (FTH) gene and investigated the effects of ferritin overexpression in FTH-Tg brain by 1H-MRI and 1H-MRS. The mice displayed no apparent neurological symptoms, and no specific morphological and T2 alterations were found in the brain by MRI, and not even by histological studies. 1H-MRS, however, revealed that some metabolic markers were significantly altered in FTH-Tg brains compared to wild-type control brains, such as decreases in myo-inositol and glutamine, and an increase in lactate. Our present studies suggested that despite the absence of neurological, morphological, T2, and histological signatures, brain metabolisms were significantly affected in FTH-Tg mice. This study also highlights the usefulness of 1H-MRS in the analysis of transgenic mouse models. |
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| 書誌情報 |
Magnetic Resonance Imaging 巻 29, 号 2, p. 179-184, 発行日 2010-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0730-725X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.mri.2010.08.013 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1016/j.mri.2010.08.013 | |||||
| 関連名称 | http://dx.doi.org/10.1016/j.mri.2010.08.013 | |||||
