@article{oai:repo.qst.go.jp:00046010,
 author = {Hasegawa, Sumitaka and Saito, Shigeyoshi and Takanashi, Junichi and Morokoshi, Yukie and Furukawa, Takako and Saga, Tsuneo and Aoki, Ichio and 長谷川 純崇 and 齋藤 茂芳 and 高梨 潤一 and 諸越 幸恵 and 古川 高子 and 佐賀 恒夫 and 青木 伊知男},
 issue = {2},
 journal = {Magnetic Resonance Imaging},
 month = {Dec},
 note = {Aberrant expression of ferritin, a major iron-binding protein, has shown to be involved in neurodegenerative diseases. In this study, we
generated transgenic (Tg) mice of human ferritin heavy chain (FTH) gene and investigated the effects of ferritin overexpression in FTH-Tg
brain by 1H-MRI and 1H-MRS. The mice displayed no apparent neurological symptoms, and no specific morphological and T2 alterations
were found in the brain by MRI, and not even by histological studies. 1H-MRS, however, revealed that some metabolic markers were
significantly altered in FTH-Tg brains compared to wild-type control brains, such as decreases in myo-inositol and glutamine, and an increase
in lactate. Our present studies suggested that despite the absence of neurological, morphological, T2, and histological signatures, brain
metabolisms were significantly affected in FTH-Tg mice. This study also highlights the usefulness of 1H-MRS in the analysis of transgenic
mouse models.},
 pages = {179--184},
 title = {Evaluation of ferritin-overexpressing brain in newly developed transgenic mice},
 volume = {29},
 year = {2010}
}