{"created":"2023-05-15T14:35:46.025705+00:00","id":46010,"links":{},"metadata":{"_buckets":{"deposit":"01a26f2b-5194-4e9d-b293-1c53d84d877c"},"_deposit":{"created_by":1,"id":"46010","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46010"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046010","sets":["1"]},"author_link":["457894","457900","457902","457889","457897","457890","457892","457898","457896","457901","457895","457893","457891","457899"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"184","bibliographicPageStart":"179","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Magnetic Resonance Imaging"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aberrant expression of ferritin, a major iron-binding protein, has shown to be involved in neurodegenerative diseases. In this study, we\ngenerated transgenic (Tg) mice of human ferritin heavy chain (FTH) gene and investigated the effects of ferritin overexpression in FTH-Tg\nbrain by 1H-MRI and 1H-MRS. The mice displayed no apparent neurological symptoms, and no specific morphological and T2 alterations\nwere found in the brain by MRI, and not even by histological studies. 1H-MRS, however, revealed that some metabolic markers were\nsignificantly altered in FTH-Tg brains compared to wild-type control brains, such as decreases in myo-inositol and glutamine, and an increase\nin lactate. Our present studies suggested that despite the absence of neurological, morphological, T2, and histological signatures, brain\nmetabolisms were significantly affected in FTH-Tg mice. This study also highlights the usefulness of 1H-MRS in the analysis of transgenic\nmouse models.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.mri.2010.08.013","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://dx.doi.org/10.1016/j.mri.2010.08.013"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.mri.2010.08.013","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0730-725X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hasegawa, Sumitaka"}],"nameIdentifiers":[{"nameIdentifier":"457889","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Shigeyoshi"}],"nameIdentifiers":[{"nameIdentifier":"457890","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takanashi, Junichi"}],"nameIdentifiers":[{"nameIdentifier":"457891","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morokoshi, Yukie"}],"nameIdentifiers":[{"nameIdentifier":"457892","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Takako"}],"nameIdentifiers":[{"nameIdentifier":"457893","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"457894","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"457895","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川 純崇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"457896","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤 茂芳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"457897","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高梨 潤一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"457898","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"諸越 幸恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"457899","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"457900","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"457901","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"457902","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Evaluation of ferritin-overexpressing brain in newly developed transgenic mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of ferritin-overexpressing brain in newly developed transgenic mice"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-03-01"},"publish_date":"2011-03-01","publish_status":"0","recid":"46010","relation_version_is_last":true,"title":["Evaluation of ferritin-overexpressing brain in newly developed transgenic mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:56:57.208103+00:00"}