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  1. 原著論文

A Prospective Study of Hypofractionated Proton Beam Therapy for Patients with Hepatocellular Carcinoma

https://repo.qst.go.jp/records/45814
https://repo.qst.go.jp/records/45814
7293abe3-44ab-487f-9c23-4c3fb8f88cd0
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-06-16
タイトル
タイトル A Prospective Study of Hypofractionated Proton Beam Therapy for Patients with Hepatocellular Carcinoma
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Fukumitsu, Nobuyoshi

× Fukumitsu, Nobuyoshi

WEKO 455537

Fukumitsu, Nobuyoshi

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Sugahara, Shinji

× Sugahara, Shinji

WEKO 455538

Sugahara, Shinji

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Nakayama, Hidetsugu

× Nakayama, Hidetsugu

WEKO 455539

Nakayama, Hidetsugu

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Tsuboi, Koji

× Tsuboi, Koji

WEKO 455540

Tsuboi, Koji

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et.al

× et.al

WEKO 455541

et.al

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菅原 信二

× 菅原 信二

WEKO 455542

en 菅原 信二

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中山 秀次

× 中山 秀次

WEKO 455543

en 中山 秀次

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坪井 康次

× 坪井 康次

WEKO 455544

en 坪井 康次

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抄録
内容記述タイプ Abstract
内容記述 PURPOSE: To evaluate the efficacy and safety of hypofractionated proton beam therapy for patients with hepatocellular carcinoma (HCC). METHODS AND MATERIALS: Between September 2001 and August 2004, 51 patients with HCC greater than 2 cm away from the porta hepatis or gastrointestinal tract were treated with proton beam therapy to 66 Gy-equivalents (GyE) in 10 fractions. RESULTS: Overall survival rates were 49.2 and 38.7% at 3 and 5 years after treatment. Local control rates were 94.5 and 87.8% at 3 and 5 years after treatment. Posttreatment serum alpha-fetoprotein values were significantly reduced when compared with pretreatment values (p < 0.0001). Patients experienced only minor acute reactions of Grade 1 or less, and 3 patients experienced late sequelae of Grade 2 or higher. However, there were no treatment-related deaths. CONCLUSIONS: Hypofractionated proton beam therapy is safe and well-tolerated by patients with HCC located greater than 2 cm away from the porta hepatis or gastrointestinal tract and may be effective alternative to other modalities.
書誌情報 International Journal of Radiation Oncology Biology Physics

巻 74, 号 3, p. 831-836, 発行日 2009-07
ISSN
収録物識別子タイプ ISSN
収録物識別子 0360-3016
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