@article{oai:repo.qst.go.jp:00045814,
 author = {Fukumitsu, Nobuyoshi and Sugahara, Shinji and Nakayama, Hidetsugu and Tsuboi, Koji and et.al and 菅原 信二 and 中山 秀次 and 坪井 康次},
 issue = {3},
 journal = {International Journal of Radiation Oncology Biology Physics},
 month = {Jul},
 note = {PURPOSE: To evaluate the efficacy and safety of hypofractionated proton beam therapy for patients with hepatocellular carcinoma (HCC). METHODS AND MATERIALS: Between September 2001 and August 2004, 51 patients with HCC greater than 2 cm away from the porta hepatis or gastrointestinal tract were treated with proton beam therapy to 66 Gy-equivalents (GyE) in 10 fractions. RESULTS: Overall survival rates were 49.2 and 38.7% at 3 and 5 years after treatment. Local control rates were 94.5 and 87.8% at 3 and 5 years after treatment. Posttreatment serum alpha-fetoprotein values were significantly reduced when compared with pretreatment values (p < 0.0001). Patients experienced only minor acute reactions of Grade 1 or less, and 3 patients experienced late sequelae of Grade 2 or higher. However, there were no treatment-related deaths. CONCLUSIONS: Hypofractionated proton beam therapy is safe and well-tolerated by patients with HCC located greater than 2 cm away from the porta hepatis or gastrointestinal tract and may be effective alternative to other modalities.},
 pages = {831--836},
 title = {A Prospective Study of Hypofractionated Proton Beam Therapy for Patients with Hepatocellular Carcinoma},
 volume = {74},
 year = {2009}
}