WEKO3
アイテム
Extrastriatal dopamine D2 receptor occupancy in olanzapine-treated patients with schizophrenia
https://repo.qst.go.jp/records/45797
https://repo.qst.go.jp/records/4579771603e5e-0b84-4b19-be75-07ec319a7773
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-05-25 | |||||
| タイトル | ||||||
| タイトル | Extrastriatal dopamine D2 receptor occupancy in olanzapine-treated patients with schizophrenia | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Arakawa, Ryosuke
× Arakawa, Ryosuke× Ito, Hiroshi× Okumura, Masaki× Takano, Akihiro× Takahashi, Hidehiko× Takano, Harumasa× Okubo, Yoshiro× Suhara, Tetsuya× 荒川 亮介× 伊藤 浩× 奥村 正紀× 高野 晶寛× 高橋 英彦× 高野 晴成× 大久保 善朗× 須原 哲也 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Olanzapine is described as a multi-acting receptor-targeted antipsychotic agent. Although regional differences of dopamine D2 receptor occupancy, i.e., limbic selectivity, were reported for olanzapine, contradictory results were also reported. We measured dopamine D2 receptor occupancy of olanzapine in extrastriatal regions in patients with schizophrenia using positron-emission tomography with [11C]FLB457 and the plasma concentrations of olanzapine. Ten patients with schizophrenia taking 5–20 mg/day of olanzapine participated. Dopamine D2 receptor occupancy in the temporal cortex ranged from 61.1 to 85.8%, and plasma concentration was from 12.7 to 115.4 ng/ml. The ED50 value was 3.4 mg/day for dose and 10.5 ng/ml for plasma concentration. The ED50 values obtained in this study were quite similar to those previously reported in the striatum. In conclusion, although the subjects and methods were different from previous striatal occupancy studies, these results suggest that limbic occupancy by olanzapine may not be so different from that in the striatum. |
|||||
| 書誌情報 |
European Archives of Psychiatry and Clinical Neuroscience 巻 260, 号 4, p. 345-350, 発行日 2010-06 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0940-1334 | |||||
