@article{oai:repo.qst.go.jp:00045797,
 author = {Arakawa, Ryosuke and Ito, Hiroshi and Okumura, Masaki and Takano, Akihiro and Takahashi, Hidehiko and Takano, Harumasa and Okubo, Yoshiro and Suhara, Tetsuya and 荒川 亮介 and 伊藤 浩 and 奥村 正紀 and 高野 晶寛 and 高橋 英彦 and 高野 晴成 and 大久保 善朗 and 須原 哲也},
 issue = {4},
 journal = {European Archives of Psychiatry and Clinical Neuroscience},
 month = {Jun},
 note = {Olanzapine is described as a multi-acting
receptor-targeted antipsychotic agent. Although regional
differences of dopamine D2 receptor occupancy, i.e., limbic
selectivity, were reported for olanzapine, contradictory
results were also reported. We measured dopamine D2
receptor occupancy of olanzapine in extrastriatal regions
in patients with schizophrenia using positron-emission
tomography with [11C]FLB457 and the plasma concentrations
of olanzapine. Ten patients with schizophrenia taking
5–20 mg/day of olanzapine participated. Dopamine D2
receptor occupancy in the temporal cortex ranged from
61.1 to 85.8%, and plasma concentration was from 12.7 to
115.4 ng/ml. The ED50 value was 3.4 mg/day for dose and
10.5 ng/ml for plasma concentration. The ED50 values
obtained in this study were quite similar to those previously
reported in the striatum. In conclusion, although the subjects
and methods were different from previous striatal
occupancy studies, these results suggest that limbic occupancy
by olanzapine may not be so different from that in
the striatum.},
 pages = {345--350},
 title = {Extrastriatal dopamine D2 receptor occupancy in olanzapine-treated patients with schizophrenia},
 volume = {260},
 year = {2010}
}