{"created":"2023-05-15T14:35:36.760062+00:00","id":45797,"links":{},"metadata":{"_buckets":{"deposit":"42ecd1f2-e4f6-4fac-9d53-66c9b41fe700"},"_deposit":{"created_by":1,"id":"45797","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45797"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045797","sets":["1"]},"author_link":["455342","455344","455337","455335","455331","455336","455339","455334","455333","455345","455346","455340","455343","455341","455332","455338"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"350","bibliographicPageStart":"345","bibliographicVolumeNumber":"260","bibliographic_titles":[{"bibliographic_title":"European Archives of Psychiatry and Clinical Neuroscience"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Olanzapine is described as a multi-acting\nreceptor-targeted antipsychotic agent. Although regional\ndifferences of dopamine D2 receptor occupancy, i.e., limbic\nselectivity, were reported for olanzapine, contradictory\nresults were also reported. We measured dopamine D2\nreceptor occupancy of olanzapine in extrastriatal regions\nin patients with schizophrenia using positron-emission\ntomography with [11C]FLB457 and the plasma concentrations\nof olanzapine. Ten patients with schizophrenia taking\n5–20 mg/day of olanzapine participated. Dopamine D2\nreceptor occupancy in the temporal cortex ranged from\n61.1 to 85.8%, and plasma concentration was from 12.7 to\n115.4 ng/ml. The ED50 value was 3.4 mg/day for dose and\n10.5 ng/ml for plasma concentration. The ED50 values\nobtained in this study were quite similar to those previously\nreported in the striatum. In conclusion, although the subjects\nand methods were different from previous striatal\noccupancy studies, these results suggest that limbic occupancy\nby olanzapine may not be so different from that in\nthe striatum.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0940-1334","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Arakawa, Ryosuke"}],"nameIdentifiers":[{"nameIdentifier":"455331","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"455332","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okumura, Masaki"}],"nameIdentifiers":[{"nameIdentifier":"455333","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takano, Akihiro"}],"nameIdentifiers":[{"nameIdentifier":"455334","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Hidehiko"}],"nameIdentifiers":[{"nameIdentifier":"455335","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takano, Harumasa"}],"nameIdentifiers":[{"nameIdentifier":"455336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okubo, Yoshiro"}],"nameIdentifiers":[{"nameIdentifier":"455337","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"455338","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川 亮介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455339","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"奥村 正紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晶寛","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455342","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 英彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455343","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455344","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保 善朗","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455346","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Extrastriatal dopamine D2 receptor occupancy in olanzapine-treated patients with schizophrenia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Extrastriatal dopamine D2 receptor occupancy in olanzapine-treated patients with schizophrenia"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-05-25"},"publish_date":"2010-05-25","publish_status":"0","recid":"45797","relation_version_is_last":true,"title":["Extrastriatal dopamine D2 receptor occupancy in olanzapine-treated patients with schizophrenia"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:59:28.937468+00:00"}