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Ultrafast LC Method for Purification and Metabolite Analysis of PET Probes.
https://repo.qst.go.jp/records/45725
https://repo.qst.go.jp/records/45725f7e21e5c-b504-435c-bb8e-b052d02f3747
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-01-08 | |||||
| タイトル | ||||||
| タイトル | Ultrafast LC Method for Purification and Metabolite Analysis of PET Probes. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakao, Ryuji
× Nakao, Ryuji× Ito, Takehito× Hayashi, Kazutaka× Fukumura, Toshimitsu× Suzuki, Kazutoshi× 中尾 隆士× 伊藤 岳人× 林 和孝× 福村 利光× 鈴木 和年 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | An ultrafast and efficient high-performance liquid chromatographic (LC) method was developed to purify positron emission tomography (PET) radiopharmaceuticals as well as for metabolite analysis of the plasma sample. Chromatographic separation was achieved on a short (60 mm length) semipreparative (10 mm I.D.) column packed with 2.5-[mu]m particles using a mixture of acetonitrile and sodium phosphate buffer as the mobile phase at a flow rate of 8–10 ml/min. Under the optimum conditions, excellent separation of the target PET probe was obtained from chemical/radiochemical impurities or radioactive metabolites with a very short run time of 2 min. This characteristic enabled significant shortening of the purification and evaporation processes in the production of short-lived radiopharmaceuticals and highly sensitive radiometric analysis with good temporal resolution during the metabolism study. | |||||
| 書誌情報 |
Nuclear Medicine and Biology 巻 37, 号 1, p. 67-72, 発行日 2010-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8051 | |||||
