@article{oai:repo.qst.go.jp:00045725,
 author = {Nakao, Ryuji and Ito, Takehito and Hayashi, Kazutaka and Fukumura, Toshimitsu and Suzuki, Kazutoshi and 中尾 隆士 and 伊藤 岳人 and 林 和孝 and 福村 利光 and 鈴木 和年},
 issue = {1},
 journal = {Nuclear Medicine and Biology},
 month = {Jan},
 note = {An ultrafast and efficient high-performance liquid chromatographic (LC) method was developed to purify positron emission tomography (PET) radiopharmaceuticals as well as for metabolite analysis of the plasma sample. Chromatographic separation was achieved on a short (60 mm length) semipreparative (10 mm I.D.) column packed with 2.5-[mu]m particles using a mixture of acetonitrile and sodium phosphate buffer as the mobile phase at a flow rate of 8–10 ml/min. Under the optimum conditions, excellent separation of the target PET probe was obtained from chemical/radiochemical impurities or radioactive metabolites with a very short run time of 2 min. This characteristic enabled significant shortening of the purification and evaporation processes in the production of short-lived radiopharmaceuticals and highly sensitive radiometric analysis with good temporal resolution during the metabolism study.},
 pages = {67--72},
 title = {Ultrafast LC Method for Purification and Metabolite Analysis of PET Probes.},
 volume = {37},
 year = {2010}
}