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Microarray-based global mapping of integration sites for the retrotransposon, intracisternal A-particle, in the mouse genome
https://repo.qst.go.jp/records/45182
https://repo.qst.go.jp/records/45182837d3dcb-10b7-4801-a207-76b08553ad78
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-06-10 | |||||
| タイトル | ||||||
| タイトル | Microarray-based global mapping of integration sites for the retrotransposon, intracisternal A-particle, in the mouse genome | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takabatake, Takashi
× Takabatake, Takashi× Ishihara, Hiroshi× Ohmachi, Yasushi× Tanaka, Izumi× M., Nakamura Masako× Fujikawa, Katsuyoshi× Hirouchi, Tokuhisa× Kakinuma, Shizuko× Shimada, Yoshiya× Oghiso, Yoichi× Tanaka, Kimio× 高畠 貴志× 石原 弘× 大町 康× 田中 泉× 柿沼 志津子× 島田 義也× 田中 公夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mammalian genomes contain numerous evolutionary harbored mobile elements, a part of which are still active and may cause genomic instability. Their movement and positional diversity occasionally result in phenotypic changes and variation by causing altered expression or disruption of neighboring host genes. Here, we describe a novel microarraybased method by which dispersed genomic locations of a type of retrotransposon in a mammalian genome can be identified. Using this method, we mapped the DNA elements for a mouse retrotransposon, intracisternal A-particle (IAP), within genomes of C3H/He and C57BL/6J inbred mouse strains; consequently we detected hundreds of probable IAP cDNA–integrated genomic regions, in which a considerable number of strain-specific putative insertions were included. In addition, by comparing genomic DNAs from radiation-induced myeloid leukemia cells and its reference normal tissue, we detected three genomic regions around which an IAP element was integrated. These results demonstrate the first successful genome-wide mapping of a retrotransposon type in a mammalian genome. |
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| 書誌情報 |
Nucleic Acids Research 巻 36, 号 10, p. e59-1-e59-11, 発行日 2008-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0305-1048 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/nar/gkn235 | |||||
