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Prediction of Lymphatic Metastasis Based on Gene Expression Profile Analysis after Brachytherapy for Early-Stage Oral Tongue Carcinoma
https://repo.qst.go.jp/records/45170
https://repo.qst.go.jp/records/45170efd02a64-9fbc-4ff8-8496-9ad9f10c178d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-05-27 | |||||
| タイトル | ||||||
| タイトル | Prediction of Lymphatic Metastasis Based on Gene Expression Profile Analysis after Brachytherapy for Early-Stage Oral Tongue Carcinoma | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Watanabe, Hiroshi
× Watanabe, Hiroshi× Miura, Masahiko× Yoshimura, Ryo-ichi× Shibuya, Hitoshi× Noda, Shuhei× Iwakawa, Mayumi× Imai, Takashi× et.al× 渡邊 裕× 三浦 雅彦× 吉村 亮一× 澁谷 均× 野田 秀平× 岩川 眞由美× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background and purpose The management of lymphatic metastasis of early-stage oral tongue carcinoma patients is crucial for its prognosis. The purpose of this study was to evaluate the predictive ability of lymphatic metastasis after brachytherapy (BRT) for early-stage tongue carcinoma based on gene expression profiling. \nPatients and methods Pre-therapeutic biopsies from 39 patients with T1 or T2 tongue cancer were analyzed for gene expression signatures using Codelink Uniset Human 20K Bioarray. All patients were treated with low dose-rate BRT for their primary lesions and underwent strict follow-up under a wait-and-see policy for cervical lymphatic metastasis. Candidate genes were selected for predicting lymph-node status in the reference group by the permutation test. Predictive accuracy was further evaluated by the prediction strength (PS) scoring system using an independent validation group. \nResults We selected a set of 19 genes whose expression differed significantly between classes with or without lymphatic metastasis in the reference group. The lymph-node status in the validation group was predicted by the PS scoring system with an accuracy of 76%. \nConclusions Gene expression profiling using 19 genes in primary tumor tissues may allow prediction of lymphatic metastasis after BRT for early-stage oral tongue carcinoma. |
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| 書誌情報 |
Radiotherapy and Oncology 巻 87, 号 2, p. 237-242, 発行日 2008-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0167-8140 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.radonc.2007.12.027 | |||||
