{"created":"2023-05-15T14:34:57.375149+00:00","id":45170,"links":{},"metadata":{"_buckets":{"deposit":"be0f038e-e645-46a1-aa3c-3af495f08ac2"},"_deposit":{"created_by":1,"id":"45170","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45170"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045170","sets":["1"]},"author_link":["448632","448641","448631","448639","448636","448642","448644","448635","448638","448633","448634","448643","448640","448637","448645"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"242","bibliographicPageStart":"237","bibliographicVolumeNumber":"87","bibliographic_titles":[{"bibliographic_title":"Radiotherapy and Oncology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and purpose\nThe management of lymphatic metastasis of early-stage oral tongue carcinoma patients is crucial for its prognosis. The purpose of this study was to evaluate the predictive ability of lymphatic metastasis after brachytherapy (BRT) for early-stage tongue carcinoma based on gene expression profiling.\n\\nPatients and methods\nPre-therapeutic biopsies from 39 patients with T1 or T2 tongue cancer were analyzed for gene expression signatures using Codelink Uniset Human 20K Bioarray. All patients were treated with low dose-rate BRT for their primary lesions and underwent strict follow-up under a wait-and-see policy for cervical lymphatic metastasis. Candidate genes were selected for predicting lymph-node status in the reference group by the permutation test. Predictive accuracy was further evaluated by the prediction strength (PS) scoring system using an independent validation group.\n\\nResults\nWe selected a set of 19 genes whose expression differed significantly between classes with or without lymphatic metastasis in the reference group. The lymph-node status in the validation group was predicted by the PS scoring system with an accuracy of 76%.\n\\nConclusions\nGene expression profiling using 19 genes in primary tumor tissues may allow prediction of lymphatic metastasis after BRT for early-stage oral tongue carcinoma.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.radonc.2007.12.027","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0167-8140","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watanabe, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"448631","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miura, Masahiko"}],"nameIdentifiers":[{"nameIdentifier":"448632","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshimura, Ryo-ichi"}],"nameIdentifiers":[{"nameIdentifier":"448633","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibuya, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"448634","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noda, Shuhei"}],"nameIdentifiers":[{"nameIdentifier":"448635","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwakawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"448636","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"448637","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"448638","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡邊 裕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三浦 雅彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448640","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉村 亮一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448641","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"澁谷 均","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448642","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野田 秀平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448643","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448645","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prediction of Lymphatic Metastasis Based on Gene Expression Profile Analysis after Brachytherapy for Early-Stage Oral Tongue Carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prediction of Lymphatic Metastasis Based on Gene Expression Profile Analysis after Brachytherapy for Early-Stage Oral Tongue Carcinoma"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-05-27"},"publish_date":"2008-05-27","publish_status":"0","recid":"45170","relation_version_is_last":true,"title":["Prediction of Lymphatic Metastasis Based on Gene Expression Profile Analysis after Brachytherapy for Early-Stage Oral Tongue Carcinoma"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:06:50.468968+00:00"}