@article{oai:repo.qst.go.jp:00045170,
 author = {Watanabe, Hiroshi and Miura, Masahiko and Yoshimura, Ryo-ichi and Shibuya, Hitoshi and Noda, Shuhei and Iwakawa, Mayumi and Imai, Takashi and et.al and 渡邊 裕 and 三浦 雅彦 and 吉村 亮一 and 澁谷 均 and 野田 秀平 and 岩川 眞由美 and 今井 高志},
 issue = {2},
 journal = {Radiotherapy and Oncology},
 month = {Jan},
 note = {Background and purpose
The management of lymphatic metastasis of early-stage oral tongue carcinoma patients is crucial for its prognosis. The purpose of this study was to evaluate the predictive ability of lymphatic metastasis after brachytherapy (BRT) for early-stage tongue carcinoma based on gene expression profiling.
\nPatients and methods
Pre-therapeutic biopsies from 39 patients with T1 or T2 tongue cancer were analyzed for gene expression signatures using Codelink Uniset Human 20K Bioarray. All patients were treated with low dose-rate BRT for their primary lesions and underwent strict follow-up under a wait-and-see policy for cervical lymphatic metastasis. Candidate genes were selected for predicting lymph-node status in the reference group by the permutation test. Predictive accuracy was further evaluated by the prediction strength (PS) scoring system using an independent validation group.
\nResults
We selected a set of 19 genes whose expression differed significantly between classes with or without lymphatic metastasis in the reference group. The lymph-node status in the validation group was predicted by the PS scoring system with an accuracy of 76%.
\nConclusions
Gene expression profiling using 19 genes in primary tumor tissues may allow prediction of lymphatic metastasis after BRT for early-stage oral tongue carcinoma.},
 pages = {237--242},
 title = {Prediction of Lymphatic Metastasis Based on Gene Expression Profile Analysis after Brachytherapy for Early-Stage Oral Tongue Carcinoma},
 volume = {87},
 year = {2008}
}