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Shortened protocol in practical [11C] SA4503-PET studies for the sigma1 receptor quantification
https://repo.qst.go.jp/records/45160
https://repo.qst.go.jp/records/45160e2895604-e5b7-40b8-89a0-2310a3090f27
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-05-16 | |||||
| タイトル | ||||||
| タイトル | Shortened protocol in practical [11C] SA4503-PET studies for the sigma1 receptor quantification | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sakata, Muneyuki
× Sakata, Muneyuki× Kimura, Yuichi× Naganawa, Mika× Ishikawa, Masatomo× Oda, Keiichi× Ishii, Kenji× Hashimoto, Kenji× Chihara, Kunihiro× Ishiwata, Kiichi× 坂田 宗之× 木村 裕一× 長縄 美香× 織田 圭一× 石井 賢二× 橋本 謙二× 石渡 喜一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In practical positron emission tomography(PET) diagnosis, a shortened protocol is preferred for patients with brain disorders. In this study, the applicability of a shortened protocol as an alternative to the 90-min PET scan with [11C]SA4503 for quantitative sigma1 receptor measurement was investigated. Tissue time-activity curves of 288 regions of interest in the brain from 32 [11C]SA4503-PET scans of 16 healthy subjects prior to and following administration of a selective serotonin reuptake inhibitor (fluvoxamine or paroxetine) were applied to two algorithms of quantitative analysis; binding potential (BP) was derived from compartmental analysis based on nonlinear estimation, and total distribution volume (tDV) was derived from Logan plot analysis. As a result, although both BP and tDV tended to be underestimated by the shortened method, the estimates from the shortened protocol had good linear relationships with those of the full-length protocol. In conclusion, if approximately 10% differences in the estimated results are acceptable for a specific purpose, then a 60-min measurement protocol is capable of providing reliable results. |
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| 書誌情報 |
Annals of Nuclear Medicine 巻 22, 号 2, p. 143-146, 発行日 2008-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-7187 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12149-007-0088-x | |||||
