@article{oai:repo.qst.go.jp:00045160,
 author = {Sakata, Muneyuki and Kimura, Yuichi and Naganawa, Mika and Ishikawa, Masatomo and Oda, Keiichi and Ishii, Kenji and Hashimoto, Kenji and Chihara, Kunihiro and Ishiwata, Kiichi and 坂田 宗之 and 木村 裕一 and 長縄 美香 and 織田 圭一 and 石井 賢二 and 橋本 謙二 and 石渡 喜一},
 issue = {2},
 journal = {Annals of Nuclear Medicine},
 month = {Mar},
 note = {In practical positron emission tomography(PET) diagnosis, a shortened protocol is preferred for patients with brain disorders. In this study, the applicability
of a shortened protocol as an alternative to the 90-min PET scan with [11C]SA4503 for quantitative sigma1 receptor measurement was investigated. Tissue time-activity curves of 288 regions of interest in the brain from 32 [11C]SA4503-PET scans of 16 healthy subjects prior to and following administration of a selective serotonin reuptake inhibitor (fluvoxamine or paroxetine) were applied to two algorithms of quantitative analysis; binding potential (BP) was derived from compartmental
analysis based on nonlinear estimation, and total distribution volume (tDV) was derived from Logan plot analysis. 
As a result, although both BP and tDV tended to be underestimated by the shortened method, the estimates from the shortened protocol had good linear relationships with those of the full-length protocol. In conclusion, if approximately 10% differences in the estimated results are acceptable for a specific purpose, then
a 60-min measurement protocol is capable of providing reliable results.},
 pages = {143--146},
 title = {Shortened protocol in practical [11C] SA4503-PET studies for the sigma1  receptor quantification},
 volume = {22},
 year = {2008}
}