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Relationship between neuroticism personality trait and serotonin transporter binding
https://repo.qst.go.jp/records/44992
https://repo.qst.go.jp/records/44992fa0d36e6-cf31-4258-b177-e4fbe7e78f82
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-10-04 | |||||
| タイトル | ||||||
| タイトル | Relationship between neuroticism personality trait and serotonin transporter binding | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takano, Akihiro
× Takano, Akihiro× Arakawa, Ryosuke× Hayashi, Mika× Takahashi, Hidehiko× Ito, Hiroshi× Suhara, Tetsuya× 高野 晶寛× 荒川 亮介× 林 海香× 高橋 英彦× 伊藤 浩× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background \nPersonality trait is thought to be one of the important factors for vulnerability to depression. The relation between serotonin transporter (5-HTT) polymorphism and anxiety-related personality has been investigated in genetic research. In this study, we investigated the relation between in vivo regional 5-HTT binding in the brain and personality inventory measures in normal male volunteers. \nMethods \nThirty-one healthy male volunteers underwent positron emission tomography scans with 11C-labeled 3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl) benzonitrile ([11C]DASB) to measure 5-HTT and completed revised NEO Personality Inventory. Correlation of [11C]DASB binding potentials (BP) with personality inventory measures was calculated using region-of-interest analysis and statistical parametric mapping based on the BP images. \nResults \nNeuroticism was positively correlated with 5-HTT binding in the thalamus (p = .004). No significant correlation was observed in any other brain region. Within the neuroticism dimension, the facet of depression was positively correlated with 5-HTT binding in the thalamus (p = .001). \nConclusions \nSubjects with higher thalamic 5-HTT binding are more likely to express higher levels of neuroticism and depressive feeling. Serotonin transporter binding in the thalamus might be a marker of vulnerability to depression. \nKey Words: [11C]DASB; depression; neuroticism; positron emission tomography; serotonin transporter; thalamus |
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| 書誌情報 |
Biological Psychiatry 巻 62, 号 6, p. 588-592, 発行日 2007-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006-3223 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.biopsych.2006.11.007 | |||||
