{"created":"2023-05-15T14:34:48.288749+00:00","id":44992,"links":{},"metadata":{"_buckets":{"deposit":"7aa498d0-5cdf-4ad3-a1e4-2f71cb47d489"},"_deposit":{"created_by":1,"id":"44992","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44992"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044992","sets":["1"]},"author_link":["446798","446793","446792","446794","446796","446800","446795","446802","446797","446801","446799","446791"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"592","bibliographicPageStart":"588","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Biological Psychiatry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\n\\nPersonality trait is thought to be one of the important factors for vulnerability to depression. The relation between serotonin transporter (5-HTT) polymorphism and anxiety-related personality has been investigated in genetic research. In this study, we investigated the relation between in vivo regional 5-HTT binding in the brain and personality inventory measures in normal male volunteers.\n\\nMethods\n\\nThirty-one healthy male volunteers underwent positron emission tomography scans with 11C-labeled 3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl) benzonitrile ([11C]DASB) to measure 5-HTT and completed revised NEO Personality Inventory. Correlation of [11C]DASB binding potentials (BP) with personality inventory measures was calculated using region-of-interest analysis and statistical parametric mapping based on the BP images.\n\\nResults\n\\nNeuroticism was positively correlated with 5-HTT binding in the thalamus (p = .004). No significant correlation was observed in any other brain region. Within the neuroticism dimension, the facet of depression was positively correlated with 5-HTT binding in the thalamus (p = .001).\n\\nConclusions\n\\nSubjects with higher thalamic 5-HTT binding are more likely to express higher levels of neuroticism and depressive feeling. Serotonin transporter binding in the thalamus might be a marker of vulnerability to depression. \n\\nKey Words: [11C]DASB; depression; neuroticism; positron emission tomography; serotonin transporter; thalamus","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.biopsych.2006.11.007","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-3223","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takano, Akihiro"}],"nameIdentifiers":[{"nameIdentifier":"446791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arakawa, Ryosuke"}],"nameIdentifiers":[{"nameIdentifier":"446792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayashi, Mika"}],"nameIdentifiers":[{"nameIdentifier":"446793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Hidehiko"}],"nameIdentifiers":[{"nameIdentifier":"446794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"446795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"446796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晶寛","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川 亮介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"林 海香","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446799","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 英彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446800","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446802","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Relationship between neuroticism personality trait and serotonin transporter binding","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relationship between neuroticism personality trait and serotonin transporter binding"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-10-04"},"publish_date":"2007-10-04","publish_status":"0","recid":"44992","relation_version_is_last":true,"title":["Relationship between neuroticism personality trait and serotonin transporter binding"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:08:56.555287+00:00"}