@article{oai:repo.qst.go.jp:00044992,
 author = {Takano, Akihiro and Arakawa, Ryosuke and Hayashi, Mika and Takahashi, Hidehiko and Ito, Hiroshi and Suhara, Tetsuya and 高野 晶寛 and 荒川 亮介 and 林 海香 and 高橋 英彦 and 伊藤 浩 and 須原 哲也},
 issue = {6},
 journal = {Biological Psychiatry},
 month = {Sep},
 note = {Background
\nPersonality trait is thought to be one of the important factors for vulnerability to depression. The relation between serotonin transporter (5-HTT) polymorphism and anxiety-related personality has been investigated in genetic research. In this study, we investigated the relation between in vivo regional 5-HTT binding in the brain and personality inventory measures in normal male volunteers.
\nMethods
\nThirty-one healthy male volunteers underwent positron emission tomography scans with 11C-labeled 3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl) benzonitrile ([11C]DASB) to measure 5-HTT and completed revised NEO Personality Inventory. Correlation of [11C]DASB binding potentials (BP) with personality inventory measures was calculated using region-of-interest analysis and statistical parametric mapping based on the BP images.
\nResults
\nNeuroticism was positively correlated with 5-HTT binding in the thalamus (p = .004). No significant correlation was observed in any other brain region. Within the neuroticism dimension, the facet of depression was positively correlated with 5-HTT binding in the thalamus (p = .001).
\nConclusions
\nSubjects with higher thalamic 5-HTT binding are more likely to express higher levels of neuroticism and depressive feeling. Serotonin transporter binding in the thalamus might be a marker of vulnerability to depression. 
\nKey Words: [11C]DASB; depression; neuroticism; positron emission tomography; serotonin transporter; thalamus},
 pages = {588--592},
 title = {Relationship between neuroticism personality trait and serotonin transporter binding},
 volume = {62},
 year = {2007}
}