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ENHANCEMENT OF CHROMOSOMAL ABERRATIONS IN TUMOR CELLS WITH A NON-LABELED CU-PTSM AND IRRADIATION WITH CU K-SHELL MONOCHOROMATIC X RAYS
https://repo.qst.go.jp/records/44878
https://repo.qst.go.jp/records/44878b5cd965f-1368-4be0-ae18-ccad6fcf506c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-06-13 | |||||
| タイトル | ||||||
| タイトル | ENHANCEMENT OF CHROMOSOMAL ABERRATIONS IN TUMOR CELLS WITH A NON-LABELED CU-PTSM AND IRRADIATION WITH CU K-SHELL MONOCHOROMATIC X RAYS | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takakura, Kaoru
× Takakura, Kaoru× Yaguchi, Satoshi× Kanasugi, Yuuichi× Kobayashi, Katsumi× Okayasu, Ryuichi× Fujibayashi, Yasuhisa× 高倉 かほる× 金杉 勇一× 小林 克己× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This study aims to clarify the enhancement effect on chromosomal aberrations via selective energy absorption by Cu atoms incultured bone cancer cells with non-labelled Cu-pyruvaldehyde-bis(N4-methylsemicarbazone) (Cu-PTSM) and monochromatic X rays. The X rays having the energy of the Cu K-shell absorption edge arising from synchrotron radiation (KEK-PF) was used as radiation source. Cu-PTSM labeled with copper radionuclides has been developed for medical imaging using positron emission tomography (PET). Evidence clearly showed that the absorption of X rays in the Cu K-shell caused this enhancement. After cells were treated with 1000 nM Cu-PTSM, the enhancement ratio of the initial yield of isochromatid breaks caused by CuK-H X-ray irradiation to that by 200 kVp X rays was 2.8. About 5.6 times of the remaining isochromatid breaks were observed at 4 h in Cu-PTSM treated samples irradiated with CuK-H X rays comparing to thatwith 200 kVp X rays. In this study, uniqueness in physical property such as Cu atom K-shell ionisation was applied for the enhancement of biological effects in cancer cells. | |||||
| 書誌情報 |
Radiation Protection Dosimetry 巻 122, 号 1-4, p. 188-194, 発行日 2007-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0144-8420 | |||||
