@article{oai:repo.qst.go.jp:00044878,
 author = {Takakura, Kaoru and Yaguchi, Satoshi and Kanasugi, Yuuichi and Kobayashi, Katsumi and Okayasu, Ryuichi and Fujibayashi, Yasuhisa and 高倉 かほる and 金杉 勇一 and 小林 克己 and 岡安 隆一},
 issue = {1-4},
 journal = {Radiation Protection Dosimetry},
 month = {Jan},
 note = {This study aims to clarify the enhancement effect on chromosomal aberrations via selective energy absorption by Cu atoms incultured bone cancer cells with non-labelled Cu-pyruvaldehyde-bis(N4-methylsemicarbazone) (Cu-PTSM) and monochromatic X rays. The X rays having the energy of the Cu K-shell absorption edge arising from synchrotron radiation (KEK-PF) was used as radiation source. Cu-PTSM labeled with copper radionuclides has been developed for medical imaging using positron emission tomography (PET). Evidence clearly showed that the absorption of X rays in the Cu K-shell caused this enhancement. After cells were treated with 1000 nM Cu-PTSM, the enhancement ratio of the initial yield of isochromatid breaks caused by CuK-H X-ray irradiation to that by 200 kVp X rays was  2.8. About 5.6 times of the remaining isochromatid breaks were observed at 4 h in Cu-PTSM treated samples irradiated with CuK-H X rays comparing to thatwith 200 kVp X rays. In this study, uniqueness in physical property such as Cu atom K-shell ionisation was applied for the enhancement of biological effects in cancer cells.},
 pages = {188--194},
 title = {ENHANCEMENT OF CHROMOSOMAL ABERRATIONS IN  TUMOR CELLS WITH A NON-LABELED CU-PTSM AND IRRADIATION WITH CU K-SHELL MONOCHOROMATIC X RAYS},
 volume = {122},
 year = {2007}
}