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The initiator motif is preferentially used as the core promoter element in ionizing radiation-responsive genes
https://repo.qst.go.jp/records/44693
https://repo.qst.go.jp/records/44693a9758992-fb6f-413b-81b2-494734deaa64
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-10-30 | |||||
| タイトル | ||||||
| タイトル | The initiator motif is preferentially used as the core promoter element in ionizing radiation-responsive genes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
K, Go
× K, Go× Daino, Kazuhiro× Ichimura, Sachiko× Nenoi, Mitsuru× 呉 健羽× 臺野 和広× 沼田 幸子× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recent improvements in DNA microarray technologies and bioinformatics have made it possible to look for common features of ionizing radiation (IR)-responsive genes and their regulatory regions. We analyzed the promoters of 217 IR- responsive human genes, compiled from microarray databases available in the literature. Using the DBTSS database, the transcriptional start sites were determined, and the core promoter elements, such as the TATA-box, initiator (Inr), GC- box and CCAAT-box, were searched for in the -1000bp/+200bp region of each gene by using MATCH. It was found that the frequency of Inr in IR-responsive genes was higher than that in general genes, and the frequency of GC-box and CCAAT-box was significantly lower than that in general genes. Utilization of the GC-box and the CCAAT-box in IR-responsive genes was found to be dependent on the TATA-box status, that is, GC-box frequency was low in TATA box-containing genes, and CCAAT-box frequency was also low in TATA-less genes. When correlations between gene functions and frequencies of core promoter elements were examined, no apparent biased use of the core promoter element in association with a specific gene function was observed. It may be speculated that utilization of Inr in the core promoter correlates with appearance of IR-responsive enhancer(silencer) elements in the upstream (downstream) regulatory region. |
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| 書誌情報 |
Radiation Research 巻 166, 号 5, p. 810-813, 発行日 2006-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
