@article{oai:repo.qst.go.jp:00044693,
 author = {K, Go and Daino, Kazuhiro and Ichimura, Sachiko and Nenoi, Mitsuru and 呉 健羽 and 臺野 和広 and 沼田 幸子 and 根井 充},
 issue = {5},
 journal = {Radiation Research},
 month = {Nov},
 note = {Recent improvements in DNA microarray technologies and bioinformatics have made it possible to look for common features of ionizing radiation (IR)-responsive genes and their regulatory regions. We analyzed the promoters of 217 IR- responsive human genes, compiled from microarray databases available in the literature. Using the DBTSS database, the transcriptional start sites were determined, and the core promoter elements, such as the TATA-box, initiator (Inr), GC- box and CCAAT-box, were searched for in the -1000bp/+200bp region of each gene by using MATCH. It was found
that the frequency of Inr in IR-responsive genes was higher than that in general genes, and the frequency of GC-box and CCAAT-box was significantly lower than that in general genes. Utilization of the GC-box and the CCAAT-box in IR-responsive genes was found to be dependent on the TATA-box status, that is, GC-box frequency was low in TATA box-containing genes, and CCAAT-box frequency was also low in TATA-less genes. When correlations between gene functions and frequencies of core promoter elements were examined, no apparent biased use of the core promoter element in association with a specific gene function was observed. It may be speculated that utilization of Inr in the core promoter correlates with appearance of IR-responsive enhancer(silencer) elements in the upstream (downstream) regulatory region.},
 pages = {810--813},
 title = {The initiator motif is preferentially used as the core promoter element in ionizing radiation-responsive genes},
 volume = {166},
 year = {2006}
}