{"created":"2023-05-15T14:34:35.178008+00:00","id":44693,"links":{},"metadata":{"_buckets":{"deposit":"2c7dddcc-ed92-4b62-9b6b-fb1a0752f819"},"_deposit":{"created_by":1,"id":"44693","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44693"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044693","sets":["1"]},"author_link":["443780","443784","443779","443783","443782","443785","443781","443786"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"813","bibliographicPageStart":"810","bibliographicVolumeNumber":"166","bibliographic_titles":[{"bibliographic_title":"Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recent improvements in DNA microarray technologies and bioinformatics have made it possible to look for common features of ionizing radiation (IR)-responsive genes and their regulatory regions. We analyzed the promoters of 217 IR- responsive human genes, compiled from microarray databases available in the literature. Using the DBTSS database, the transcriptional start sites were determined, and the core promoter elements, such as the TATA-box, initiator (Inr), GC- box and CCAAT-box, were searched for in the -1000bp/+200bp region of each gene by using MATCH. It was found\nthat the frequency of Inr in IR-responsive genes was higher than that in general genes, and the frequency of GC-box and CCAAT-box was significantly lower than that in general genes. Utilization of the GC-box and the CCAAT-box in IR-responsive genes was found to be dependent on the TATA-box status, that is, GC-box frequency was low in TATA box-containing genes, and CCAAT-box frequency was also low in TATA-less genes. When correlations between gene functions and frequencies of core promoter elements were examined, no apparent biased use of the core promoter element in association with a specific gene function was observed. It may be speculated that utilization of Inr in the core promoter correlates with appearance of IR-responsive enhancer(silencer) elements in the upstream (downstream) regulatory region.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0033-7587","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"K, Go"}],"nameIdentifiers":[{"nameIdentifier":"443779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Daino, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"443780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichimura, Sachiko"}],"nameIdentifiers":[{"nameIdentifier":"443781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nenoi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"443782","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"呉 健羽","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"443783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"臺野 和広","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"443784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"沼田 幸子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"443785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"443786","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The initiator motif is preferentially used as the core promoter element in ionizing radiation-responsive genes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The initiator motif is preferentially used as the core promoter element in ionizing radiation-responsive genes"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-10-30"},"publish_date":"2006-10-30","publish_status":"0","recid":"44693","relation_version_is_last":true,"title":["The initiator motif is preferentially used as the core promoter element in ionizing radiation-responsive genes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:12:27.510874+00:00"}