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N-Methyl-3-(I-Hydroxy-5-[123I]Iodopent-4-enyl)-4-Acetoxypipe ridine, A Novel Candidate of Acetylcholinesterase Activity Imaging Agent
https://repo.qst.go.jp/records/44455
https://repo.qst.go.jp/records/44455887eb622-3e33-4b9e-abc8-7135ead765bb
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-07-07 | |||||
| タイトル | ||||||
| タイトル | N-Methyl-3-(I-Hydroxy-5-[123I]Iodopent-4-enyl)-4-Acetoxypipe ridine, A Novel Candidate of Acetylcholinesterase Activity Imaging Agent | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ueda, Takao
× Ueda, Takao× Irie, Toshiaki× Fukushi, Kiyoshi× Ikota, Nobuo× Takatoku, Keizo× Yomoda, Isamu× Nagatsuka, Shinnichiro× 入江 俊章× 福士 清× 伊古田 暢夫× 長塚 伸一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A novel acetylcholine radioanalog, N-methyl-3-(l-hydroxy-5-[123I]iodopent-4-enyl)-4-acetoxypiperidine, was prepared by radioiodination of the corresponding tributylstannyl precursor that was synthesized in eight steps from 4-piperidone. The tracer has three asymmetric carbons giving eight opical isomers. Two optical isomers were isolated in the precursor synthesis by diastereomeric and enantiomeric separation. In the incubation experiments using rat cerebral homogenate, one optical isomer was hydrolyzed by acetylcholinesterase with high reactivity and selectivity. The tracer is a candidate for mapping cerebral regional acetylcholinesterase activity by single photon emission computed tomography. | |||||
| 書誌情報 |
Journal of Labelled Compounds & Radiopharmaceuticals 巻 43, p. 753-765, 発行日 2000 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0362-4803 | |||||
