{"created":"2023-05-15T14:34:24.596650+00:00","id":44455,"links":{},"metadata":{"_buckets":{"deposit":"2b8836b4-2aff-426d-bcef-ab71632ed8b3"},"_deposit":{"created_by":1,"id":"44455","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44455"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044455","sets":["1"]},"author_link":["441770","441772","441780","441778","441771","441774","441773","441777","441779","441776","441775"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"765","bibliographicPageStart":"753","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Journal of Labelled Compounds & Radiopharmaceuticals"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A novel acetylcholine radioanalog, N-methyl-3-(l-hydroxy-5-[123I]iodopent-4-enyl)-4-acetoxypiperidine, was prepared by radioiodination of the corresponding tributylstannyl precursor that was synthesized in eight steps from 4-piperidone.  The tracer has three asymmetric carbons giving eight opical isomers. Two optical isomers were isolated in the precursor synthesis by diastereomeric and enantiomeric separation.  In the incubation experiments using rat cerebral homogenate, one optical isomer was hydrolyzed by acetylcholinesterase with high reactivity and selectivity.  The tracer is a candidate for mapping cerebral regional acetylcholinesterase activity by single photon emission computed tomography.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0362-4803","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ueda, Takao"}],"nameIdentifiers":[{"nameIdentifier":"441770","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Irie, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"441771","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukushi, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"441772","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikota, Nobuo"}],"nameIdentifiers":[{"nameIdentifier":"441773","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takatoku, Keizo"}],"nameIdentifiers":[{"nameIdentifier":"441774","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yomoda, Isamu"}],"nameIdentifiers":[{"nameIdentifier":"441775","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagatsuka, Shinnichiro"}],"nameIdentifiers":[{"nameIdentifier":"441776","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441777","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441778","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊古田 暢夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長塚 伸一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441780","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"N-Methyl-3-(I-Hydroxy-5-[123I]Iodopent-4-enyl)-4-Acetoxypipe ridine, A Novel Candidate of Acetylcholinesterase Activity Imaging Agent","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"N-Methyl-3-(I-Hydroxy-5-[123I]Iodopent-4-enyl)-4-Acetoxypipe ridine, A Novel Candidate of Acetylcholinesterase Activity Imaging Agent"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-07-07"},"publish_date":"2006-07-07","publish_status":"0","recid":"44455","relation_version_is_last":true,"title":["N-Methyl-3-(I-Hydroxy-5-[123I]Iodopent-4-enyl)-4-Acetoxypipe ridine, A Novel Candidate of Acetylcholinesterase Activity Imaging Agent"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:15:15.802802+00:00"}