@article{oai:repo.qst.go.jp:00044455,
 author = {Ueda, Takao and Irie, Toshiaki and Fukushi, Kiyoshi and Ikota, Nobuo and Takatoku, Keizo and Yomoda, Isamu and Nagatsuka, Shinnichiro and 入江 俊章 and 福士 清 and 伊古田 暢夫 and 長塚 伸一郎},
 journal = {Journal of Labelled Compounds & Radiopharmaceuticals},
 month = {},
 note = {A novel acetylcholine radioanalog, N-methyl-3-(l-hydroxy-5-[123I]iodopent-4-enyl)-4-acetoxypiperidine, was prepared by radioiodination of the corresponding tributylstannyl precursor that was synthesized in eight steps from 4-piperidone.  The tracer has three asymmetric carbons giving eight opical isomers. Two optical isomers were isolated in the precursor synthesis by diastereomeric and enantiomeric separation.  In the incubation experiments using rat cerebral homogenate, one optical isomer was hydrolyzed by acetylcholinesterase with high reactivity and selectivity.  The tracer is a candidate for mapping cerebral regional acetylcholinesterase activity by single photon emission computed tomography.},
 pages = {753--765},
 title = {N-Methyl-3-(I-Hydroxy-5-[123I]Iodopent-4-enyl)-4-Acetoxypipe ridine, A Novel Candidate of Acetylcholinesterase Activity Imaging Agent},
 volume = {43},
 year = {2000}
}