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N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: a novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography
https://repo.qst.go.jp/records/44354
https://repo.qst.go.jp/records/4435484d17d65-be75-4dbc-8cb9-9c81a9b56e9f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-26 | |||||
| タイトル | ||||||
| タイトル | N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: a novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kikuchi, Tatsuya
× Kikuchi, Tatsuya× Zhang, Ming-Rong× Ikota, Nobuo× Fukushi, Kiyoshi× Okamura, Toshimitsu× Suzuki, Kazutoshi× Arano, Yasushi× Irie, Toshiaki× 菊池 達矢× 張 明栄× 伊古田 暢夫× 福士 清× 岡村 敏充× 鈴木 和年× 荒野 泰× 入江 俊章 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In Alzheimer's disease, cerebral cortical butyrylcholinesterase (BChE) activity is reported to be elevated. Our aim was to develop a novel 18F-labeled tracer for quantifying cerebral BChE activity by positron emission tomography. With in vitro screening of N-[14C]ethylpiperidin-3-and 4-ylmethyl esters. N-[14C]ethylpiperidin-4-ylmethyl butyrate was selected as a lead for 18F-labeling, affording N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate. The 18F-labeled butyrate showed the required properties for in vivo BChe measurement, that is, the lipophilic nature of the authentic ester, high specificity to BChE, a moderate hydroysis rete, and the hydrophilic nature of the metabolite. | |||||
| 書誌情報 |
Bioorganic & Medicinal Chemistry Letters 巻 14, p. 1927-1930, 発行日 2004 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0960-894X | |||||
