@article{oai:repo.qst.go.jp:00044354,
 author = {Kikuchi, Tatsuya and Zhang, Ming-Rong and Ikota, Nobuo and Fukushi, Kiyoshi and Okamura, Toshimitsu and Suzuki, Kazutoshi and Arano, Yasushi and Irie, Toshiaki and 菊池 達矢 and 張 明栄 and 伊古田 暢夫 and 福士 清 and 岡村 敏充 and 鈴木 和年 and 荒野 泰 and 入江 俊章},
 journal = {Bioorganic & Medicinal Chemistry Letters},
 month = {},
 note = {In Alzheimer's disease, cerebral cortical butyrylcholinesterase (BChE) activity is reported to be elevated. Our aim was to develop a novel 18F-labeled tracer for quantifying cerebral BChE activity by positron emission tomography. With in vitro screening of N-[14C]ethylpiperidin-3-and 4-ylmethyl esters. N-[14C]ethylpiperidin-4-ylmethyl butyrate was selected as a lead for 18F-labeling, affording N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate. The 18F-labeled butyrate showed the required properties for in vivo BChe measurement, that is, the lipophilic nature of the authentic ester, high specificity to BChE, a moderate hydroysis rete, and the hydrophilic nature of the metabolite.},
 pages = {1927--1930},
 title = {N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: a novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography},
 volume = {14},
 year = {2004}
}