{"created":"2023-05-15T14:34:18.492136+00:00","id":44354,"links":{},"metadata":{"_buckets":{"deposit":"be7c1534-6e77-41ec-8d18-7820c8d689a9"},"_deposit":{"created_by":1,"id":"44354","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44354"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044354","sets":["1"]},"author_link":["440653","440645","440643","440649","440651","440652","440646","440648","440644","440642","440654","440656","440650","440647","440655","440657"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"1930","bibliographicPageStart":"1927","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medicinal Chemistry Letters"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In Alzheimer's disease, cerebral cortical butyrylcholinesterase (BChE) activity is reported to be elevated. Our aim was to develop a novel 18F-labeled tracer for quantifying cerebral BChE activity by positron emission tomography. With in vitro screening of N-[14C]ethylpiperidin-3-and 4-ylmethyl esters. N-[14C]ethylpiperidin-4-ylmethyl butyrate was selected as a lead for 18F-labeling, affording N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate. The 18F-labeled butyrate showed the required properties for in vivo BChe measurement, that is, the lipophilic nature of the authentic ester, high specificity to BChE, a moderate hydroysis rete, and the hydrophilic nature of the metabolite.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0960-894X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kikuchi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"440642","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"440643","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikota, Nobuo"}],"nameIdentifiers":[{"nameIdentifier":"440644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukushi, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"440645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamura, Toshimitsu"}],"nameIdentifiers":[{"nameIdentifier":"440646","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Kazutoshi"}],"nameIdentifiers":[{"nameIdentifier":"440647","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arano, Yasushi"}],"nameIdentifiers":[{"nameIdentifier":"440648","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Irie, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"440649","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池 達矢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440650","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊古田 暢夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440652","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440653","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡村 敏充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒野 泰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440657","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: a novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: a novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-26"},"publish_date":"2006-06-26","publish_status":"0","recid":"44354","relation_version_is_last":true,"title":["N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: a novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:16:27.104766+00:00"}