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Development of an automated system for synthesizing 18F-labeled compounds using [18F]fluoroethyl bromide as a synthetic precursor
https://repo.qst.go.jp/records/44323
https://repo.qst.go.jp/records/443237521594b-00d0-415d-9b5e-c26d2a535874
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-23 | |||||
| タイトル | ||||||
| タイトル | Development of an automated system for synthesizing 18F-labeled compounds using [18F]fluoroethyl bromide as a synthetic precursor | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zhang, Ming-Rong
× Zhang, Ming-Rong× Tsuchiyama, Akio× Haradahira, Terushi× Yoshida, Yuichirou× Furutsuka, Kenji× Suzuki, Kazutoshi× 張 明栄× 原田平 輝志× 吉田 勇一郎× 古塚 賢士× 鈴木 和年 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | An automated system was developed to synthesize 18F-labeled compounds using [18F]fluoroethyl bromide ([18F]FEtBr)as a synthetic precursor. The apparatus makes possible the following sequence of processes: (1)production of an aqueous solution of [18F]fluoride([18F]F-),(2)recovery of [18F]F-from target chamber, (3)drying of [18F]F-,(4)formation and distillation of [18F]FEtBr into a trapping vessel, (5)alkylation of target compounds with [18F]FEtBr,(6)High performance liquid chromatography purification and (7)formulation. [18F]FEtBr,the synthetic precursor for fluoroethylation, was labeled via nucleophilic displacement of 2-trifluoromethanesulfonyloxy ethylbromide (BrCH2CH2OTf)with [18F]F- and was purified from the reaction mixture by distillation. After the conditions for forming [18F]FEtBr and drying [18F]F- were optimized,[18F]FEtBr was obtained in a radiochemical yield of 71+/-13%(n=21,based on [18F]F-,corrected for decay) and a radiochemical purity of 98+/-1.4% at end of the syntheses (EOS). Using this automated system,[18F]fluoroethylspiperone ([18F]FEtSP) was prepared by reacting spiperone with[18F]FEtBr in a radiochemical yield and purity of 56+/-12%(n=5,based on [18F]FEtBr, corrected for decay) and 97+/-1.5% with a specific activity of 310+/-120GBq/mumol at EOS. The total synthesis time was 55+/-2.3min from the end of bombardment and the developed system has proved to be reliable and reproducible. |
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| 書誌情報 |
Applied Radiation and Isotopes 巻 57, p. 335-342, 発行日 2002 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8043 | |||||
