@article{oai:repo.qst.go.jp:00044323,
 author = {Zhang, Ming-Rong and Tsuchiyama, Akio and Haradahira, Terushi and Yoshida, Yuichirou and Furutsuka, Kenji and Suzuki, Kazutoshi and 張 明栄 and 原田平 輝志 and 吉田 勇一郎 and 古塚 賢士 and 鈴木 和年},
 journal = {Applied Radiation and Isotopes},
 month = {},
 note = {An automated system was developed to synthesize 18F-labeled compounds using
[18F]fluoroethyl bromide ([18F]FEtBr)as a synthetic precursor. The apparatus makes possible the following sequence of processes: (1)production of an aqueous solution of [18F]fluoride([18F]F-),(2)recovery of [18F]F-from target chamber, (3)drying of [18F]F-,(4)formation and distillation of [18F]FEtBr into a trapping vessel, (5)alkylation of target compounds with [18F]FEtBr,(6)High performance liquid chromatography purification and (7)formulation. [18F]FEtBr,the synthetic precursor for fluoroethylation, was labeled via nucleophilic displacement of 2-trifluoromethanesulfonyloxy ethylbromide (BrCH2CH2OTf)with [18F]F- and was purified from the reaction mixture by distillation. After the conditions for forming [18F]FEtBr and drying [18F]F- were optimized,[18F]FEtBr was obtained in a radiochemical yield of 71+/-13%(n=21,based on [18F]F-,corrected for decay) and a radiochemical purity of 98+/-1.4% at end of the syntheses (EOS). Using this automated system,[18F]fluoroethylspiperone ([18F]FEtSP) was prepared by reacting spiperone with[18F]FEtBr in a radiochemical yield and purity of 56+/-12%(n=5,based on [18F]FEtBr, corrected for decay) and 97+/-1.5% with a specific activity of 310+/-120GBq/mumol at EOS. The total synthesis time was 55+/-2.3min from the end of bombardment and the developed system has proved to be reliable and reproducible.},
 pages = {335--342},
 title = {Development of an automated system for synthesizing 18F-labeled compounds using [18F]fluoroethyl bromide as a synthetic precursor},
 volume = {57},
 year = {2002}
}