{"created":"2023-05-15T14:34:16.442310+00:00","id":44323,"links":{},"metadata":{"_buckets":{"deposit":"8ddfe7f1-6c6a-44fb-a7c9-8bf91c31fdaf"},"_deposit":{"created_by":1,"id":"44323","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44323"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044323","sets":["1"]},"author_link":["440273","440278","440280","440282","440283","440276","440281","440275","440274","440277","440279"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"342","bibliographicPageStart":"335","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Applied Radiation and Isotopes"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"An automated system was developed to synthesize 18F-labeled compounds using\n[18F]fluoroethyl bromide ([18F]FEtBr)as a synthetic precursor. The apparatus makes possible the following sequence of processes: (1)production of an aqueous solution of [18F]fluoride([18F]F-),(2)recovery of [18F]F-from target chamber, (3)drying of [18F]F-,(4)formation and distillation of [18F]FEtBr into a trapping vessel, (5)alkylation of target compounds with [18F]FEtBr,(6)High performance liquid chromatography purification and (7)formulation. [18F]FEtBr,the synthetic precursor for fluoroethylation, was labeled via nucleophilic displacement of 2-trifluoromethanesulfonyloxy ethylbromide (BrCH2CH2OTf)with [18F]F- and was purified from the reaction mixture by distillation. After the conditions for forming [18F]FEtBr and drying [18F]F- were optimized,[18F]FEtBr was obtained in a radiochemical yield of 71+/-13%(n=21,based on [18F]F-,corrected for decay) and a radiochemical purity of 98+/-1.4% at end of the syntheses (EOS). Using this automated system,[18F]fluoroethylspiperone ([18F]FEtSP) was prepared by reacting spiperone with[18F]FEtBr in a radiochemical yield and purity of 56+/-12%(n=5,based on [18F]FEtBr, corrected for decay) and 97+/-1.5% with a specific activity of 310+/-120GBq/mumol at EOS. The total synthesis time was 55+/-2.3min from the end of bombardment and the developed system has proved to be reliable and reproducible.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0969-8043","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"440273","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuchiyama, Akio"}],"nameIdentifiers":[{"nameIdentifier":"440274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Haradahira, Terushi"}],"nameIdentifiers":[{"nameIdentifier":"440275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Yuichirou"}],"nameIdentifiers":[{"nameIdentifier":"440276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furutsuka, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"440277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Kazutoshi"}],"nameIdentifiers":[{"nameIdentifier":"440278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原田平 輝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 勇一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古塚 賢士","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440282","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440283","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Development of an automated system for synthesizing 18F-labeled compounds using [18F]fluoroethyl bromide as a synthetic precursor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of an automated system for synthesizing 18F-labeled compounds using [18F]fluoroethyl bromide as a synthetic precursor"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-23"},"publish_date":"2006-06-23","publish_status":"0","recid":"44323","relation_version_is_last":true,"title":["Development of an automated system for synthesizing 18F-labeled compounds using [18F]fluoroethyl bromide as a synthetic precursor"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:16:48.567681+00:00"}