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A Positron-Emitter Labeled GlycineB Site Antagonist, [11C]L-703,717, Preferentially Binds to a Cerebellar NMDA Receptor Subtype Consisting of GluR epsilon3 Subunit In Vivo, But Not In Vitro
https://repo.qst.go.jp/records/44322
https://repo.qst.go.jp/records/44322aec40050-39a6-4109-8df0-f5ba0360a890
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-23 | |||||
| タイトル | ||||||
| タイトル | A Positron-Emitter Labeled GlycineB Site Antagonist, [11C]L-703,717, Preferentially Binds to a Cerebellar NMDA Receptor Subtype Consisting of GluR epsilon3 Subunit In Vivo, But Not In Vitro | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Haradahira, Terushi
× Haradahira, Terushi× Okauchi, Takashi× Maeda, Jun× Zhang, Ming-Rong× Kida, Takayo× Kawabe, Koichi× Mishina, Masahiro× Watanabe, Yasuyoshi× Suzuki, Kazutoshi× Suhara, Tetsuya× 原田平 輝志× 岡内 隆× 前田 純× 張 明栄× 鈴木 和年× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In previous studies, we have found that [11C]L-703,717,a positron-emitter labeled antagonist for the glycine-binding site of NMDA receptors,only localizes in rodent cerebellum under in vivo conditions. In order to understand the unusual cerebellar localization,we have examined the binding of [11C]L-703,717 to a cerebellar specific NMDA receptor subtype consisting of GLuRepsilon3 subunit,by comparing its auto-radiographic distributions between GluRepsilon3-deficient and wild-type mice. Ex vivo [11C]L-703,717 binding to wild-type mice showed a highly specific localization of radioactivity in the cerebellum,whereas that to the GluRepsilon3-deficient mice showed no specific localization of radioactivity in any of the brain regions. In contrast to the ex vivo binding,in vitro[11C]L-703,717 binding displayed a similar binding characteristic between GluRepsilon3-deficient and wild-type mice with highly specific localizations in the hippocampus and cerebral cortex. Therefore,the present study clearly demonstrated that [11C]L-703,717 preferentially binds to a cerebellar NMDA receptor subtype consisting of GluRepsilon3 subunit in vivo,but not in vitro. Synapse 43:131-133,2002. (C)2001 Wiley-Liss,Inc. |
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| 書誌情報 |
Synapse 巻 43, p. 131-133, 発行日 2002 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0887-4476 | |||||
