{"created":"2023-05-15T14:34:16.376569+00:00","id":44322,"links":{},"metadata":{"_buckets":{"deposit":"16e5d351-24d9-4c6d-a389-4a743bf117c4"},"_deposit":{"created_by":1,"id":"44322","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44322"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044322","sets":["1"]},"author_link":["440267","440270","440262","440266","440269","440263","440264","440265","440268","440257","440260","440258","440259","440261","440271","440272"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"133","bibliographicPageStart":"131","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Synapse"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In previous studies, we have found that [11C]L-703,717,a positron-emitter labeled antagonist for the glycine-binding site of NMDA receptors,only localizes in rodent cerebellum under in vivo conditions. In order to understand the unusual cerebellar localization,we have examined the binding of [11C]L-703,717 to a cerebellar specific NMDA receptor subtype consisting of GLuRepsilon3 subunit,by comparing its auto-radiographic distributions between  GluRepsilon3-deficient and wild-type mice. Ex vivo [11C]L-703,717 binding to wild-type mice showed a highly specific localization of radioactivity in the cerebellum,whereas that to the GluRepsilon3-deficient mice showed no specific localization of radioactivity in any of the brain regions. In contrast to the ex vivo binding,in vitro[11C]L-703,717 binding displayed a similar binding characteristic between GluRepsilon3-deficient and wild-type mice with highly specific localizations in the hippocampus and cerebral cortex. Therefore,the present study clearly demonstrated that [11C]L-703,717 preferentially binds to a cerebellar NMDA receptor subtype consisting of GluRepsilon3 subunit in vivo,but not in vitro. Synapse 43:131-133,2002.\n(C)2001 Wiley-Liss,Inc.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0887-4476","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Haradahira, Terushi"}],"nameIdentifiers":[{"nameIdentifier":"440257","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okauchi, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"440258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Jun"}],"nameIdentifiers":[{"nameIdentifier":"440259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"440260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kida, Takayo"}],"nameIdentifiers":[{"nameIdentifier":"440261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawabe, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"440262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mishina, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"440263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Yasuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"440264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Kazutoshi"}],"nameIdentifiers":[{"nameIdentifier":"440265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"440266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原田平 輝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡内 隆","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 純","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440271","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440272","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Positron-Emitter Labeled GlycineB Site Antagonist, [11C]L-703,717, Preferentially Binds to a Cerebellar NMDA Receptor Subtype Consisting of GluR epsilon3 Subunit In Vivo, But Not In Vitro","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Positron-Emitter Labeled GlycineB Site Antagonist, [11C]L-703,717, Preferentially Binds to a Cerebellar NMDA Receptor Subtype Consisting of GluR epsilon3 Subunit In Vivo, But Not In Vitro"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-23"},"publish_date":"2006-06-23","publish_status":"0","recid":"44322","relation_version_is_last":true,"title":["A Positron-Emitter Labeled GlycineB Site Antagonist, [11C]L-703,717, Preferentially Binds to a Cerebellar NMDA Receptor Subtype Consisting of GluR epsilon3 Subunit In Vivo, But Not In Vitro"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:16:49.266273+00:00"}