@article{oai:repo.qst.go.jp:00044322,
 author = {Haradahira, Terushi and Okauchi, Takashi and Maeda, Jun and Zhang, Ming-Rong and Kida, Takayo and Kawabe, Koichi and Mishina, Masahiro and Watanabe, Yasuyoshi and Suzuki, Kazutoshi and Suhara, Tetsuya and 原田平 輝志 and 岡内 隆 and 前田 純 and 張 明栄 and 鈴木 和年 and 須原 哲也},
 journal = {Synapse},
 month = {},
 note = {In previous studies, we have found that [11C]L-703,717,a positron-emitter labeled antagonist for the glycine-binding site of NMDA receptors,only localizes in rodent cerebellum under in vivo conditions. In order to understand the unusual cerebellar localization,we have examined the binding of [11C]L-703,717 to a cerebellar specific NMDA receptor subtype consisting of GLuRepsilon3 subunit,by comparing its auto-radiographic distributions between  GluRepsilon3-deficient and wild-type mice. Ex vivo [11C]L-703,717 binding to wild-type mice showed a highly specific localization of radioactivity in the cerebellum,whereas that to the GluRepsilon3-deficient mice showed no specific localization of radioactivity in any of the brain regions. In contrast to the ex vivo binding,in vitro[11C]L-703,717 binding displayed a similar binding characteristic between GluRepsilon3-deficient and wild-type mice with highly specific localizations in the hippocampus and cerebral cortex. Therefore,the present study clearly demonstrated that [11C]L-703,717 preferentially binds to a cerebellar NMDA receptor subtype consisting of GluRepsilon3 subunit in vivo,but not in vitro. Synapse 43:131-133,2002.
(C)2001 Wiley-Liss,Inc.},
 pages = {131--133},
 title = {A Positron-Emitter Labeled GlycineB Site Antagonist, [11C]L-703,717, Preferentially Binds to a Cerebellar NMDA Receptor Subtype Consisting of GluR epsilon3 Subunit In Vivo, But Not In Vitro},
 volume = {43},
 year = {2002}
}