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SYNTHESIS AND PRELIMINARY EVALUATION OF [18F]FEtP4A,A PROMISING PET TRACER FOR MAPPING ACETYLCHOLINESTERASE IN VIVO
https://repo.qst.go.jp/records/44314
https://repo.qst.go.jp/records/443143e443dde-42e6-4a9b-b25d-315a47d51182
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2006-06-21 | |||||
タイトル | ||||||
タイトル | SYNTHESIS AND PRELIMINARY EVALUATION OF [18F]FEtP4A,A PROMISING PET TRACER FOR MAPPING ACETYLCHOLINESTERASE IN VIVO | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Zhang, Ming-Rong
× Zhang, Ming-Rong× Tsuchiyama, Akio× Haradahira, Terushi× Furutsuka, Kenji× Yoshida, Yuichirou× Kida, Takayo× Noguchi, Junko× Irie, Toshiaki× Suzuki, Kazutoshi× 張 明栄× 原田平 輝志× 古塚 賢士× 吉田 勇一郎× 入江 俊章× 鈴木 和年 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | N-[18F]Fluoroethyl-4-piperidyl acetate([18F]FEtP4A),an analog of [11C]MP4A for mapping brain acetylcholineseterase(AchE)activity,was prepared by reacting 4-piperidyl acetate(P4A)with [18F]fluoroethyl bromide([18F]FEtBr) using a newly developed automated system.Preliminary evaluation showed that the initial uptake of [18F]FEtP4A in the mouse brain was>8% injected dose/g tissue.The distribution pattern of[18F]FEtP4A in the brain was striatum >cerebral cortex>cerebellum within 10-120 min post-injection,which reflected the distribution rank pattern of AchE activity in the brain. Moreover,chemical analysis of in vivo radioactive metabolites in the mouse brain indicated that 83% of [18F]FEtP4A was hydrolyzed to N-[18F]fluoroethy1-4-piperidinol([18F]FEtP4OH)after 1 min intravenous injection. From these results,[18F]FEtP4A may become a promising PET tracer for mapping the AchE in vivo. | |||||
書誌情報 |
Nuclear Medicine and Biology 巻 29, 号 4, p. 463-468, 発行日 2002-05 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0969-8051 |