@article{oai:repo.qst.go.jp:00044314,
 author = {Zhang, Ming-Rong and Tsuchiyama, Akio and Haradahira, Terushi and Furutsuka, Kenji and Yoshida, Yuichirou and Kida, Takayo and Noguchi, Junko and Irie, Toshiaki and Suzuki, Kazutoshi and 張 明栄 and 原田平 輝志 and 古塚 賢士 and 吉田 勇一郎 and 入江 俊章 and 鈴木 和年},
 issue = {4},
 journal = {Nuclear Medicine and Biology},
 month = {May},
 note = {N-[18F]Fluoroethyl-4-piperidyl acetate([18F]FEtP4A),an analog of [11C]MP4A for mapping brain acetylcholineseterase(AchE)activity,was prepared by reacting 4-piperidyl acetate(P4A)with [18F]fluoroethyl bromide([18F]FEtBr) using a newly developed automated system.Preliminary evaluation showed that the initial uptake of [18F]FEtP4A in the mouse brain was>8% injected dose/g tissue.The distribution pattern of[18F]FEtP4A in the brain was striatum >cerebral cortex>cerebellum within 10-120 min post-injection,which reflected the distribution rank pattern of AchE activity in the brain. Moreover,chemical analysis of in vivo radioactive metabolites in the mouse brain indicated that 83% of [18F]FEtP4A was hydrolyzed to N-[18F]fluoroethy1-4-piperidinol([18F]FEtP4OH)after 1 min intravenous injection. From these results,[18F]FEtP4A may become a promising PET tracer for mapping the AchE in vivo.},
 pages = {463--468},
 title = {SYNTHESIS AND PRELIMINARY EVALUATION OF [18F]FEtP4A,A PROMISING PET TRACER FOR MAPPING ACETYLCHOLINESTERASE IN VIVO},
 volume = {29},
 year = {2002}
}