{"created":"2023-05-15T14:34:15.844724+00:00","id":44314,"links":{},"metadata":{"_buckets":{"deposit":"918bfc25-39bb-41d7-af8a-0e2a17faf185"},"_deposit":{"created_by":1,"id":"44314","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44314"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044314","sets":["1"]},"author_link":["440184","440183","440177","440181","440174","440182","440176","440180","440179","440175","440185","440172","440171","440178","440173"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"468","bibliographicPageStart":"463","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Nuclear Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"N-[18F]Fluoroethyl-4-piperidyl acetate([18F]FEtP4A),an analog of [11C]MP4A for mapping brain acetylcholineseterase(AchE)activity,was prepared by reacting 4-piperidyl acetate(P4A)with [18F]fluoroethyl bromide([18F]FEtBr) using a newly developed automated system.Preliminary evaluation showed that the initial uptake of [18F]FEtP4A in the mouse brain was>8% injected dose/g tissue.The distribution pattern of[18F]FEtP4A in the brain was striatum >cerebral cortex>cerebellum within 10-120 min post-injection,which reflected the distribution rank pattern of AchE activity in the brain. Moreover,chemical analysis of in vivo radioactive metabolites in the mouse brain indicated that 83% of [18F]FEtP4A was hydrolyzed to N-[18F]fluoroethy1-4-piperidinol([18F]FEtP4OH)after 1 min intravenous injection. From these results,[18F]FEtP4A may become a promising PET tracer for mapping the AchE in vivo.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0969-8051","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"440171","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuchiyama, Akio"}],"nameIdentifiers":[{"nameIdentifier":"440172","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Haradahira, Terushi"}],"nameIdentifiers":[{"nameIdentifier":"440173","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furutsuka, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"440174","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Yuichirou"}],"nameIdentifiers":[{"nameIdentifier":"440175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kida, Takayo"}],"nameIdentifiers":[{"nameIdentifier":"440176","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noguchi, Junko"}],"nameIdentifiers":[{"nameIdentifier":"440177","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Irie, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"440178","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Kazutoshi"}],"nameIdentifiers":[{"nameIdentifier":"440179","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原田平 輝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440181","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古塚 賢士","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440182","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 勇一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440183","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440184","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440185","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"SYNTHESIS AND PRELIMINARY EVALUATION OF [18F]FEtP4A,A PROMISING PET TRACER FOR MAPPING ACETYLCHOLINESTERASE IN VIVO","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SYNTHESIS AND PRELIMINARY EVALUATION OF [18F]FEtP4A,A PROMISING PET TRACER FOR MAPPING ACETYLCHOLINESTERASE IN VIVO"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-21"},"publish_date":"2006-06-21","publish_status":"0","recid":"44314","relation_version_is_last":true,"title":["SYNTHESIS AND PRELIMINARY EVALUATION OF [18F]FEtP4A,A PROMISING PET TRACER FOR MAPPING ACETYLCHOLINESTERASE IN VIVO"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:16:55.050980+00:00"}