WEKO3
アイテム
{"_buckets": {"deposit": "8cdf1305-3f69-42a9-825d-aeb7d5629007"}, "_deposit": {"created_by": 1, "id": "44088", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "44088"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00044088", "sets": ["1"]}, "author_link": ["438287", "438286", "438298", "438293", "438297", "438289", "438292", "438285", "438290", "438295", "438288", "438294", "438291", "438296"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1999-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "4000", "bibliographicPageStart": "397", "bibliographicVolumeNumber": "13", "bibliographic_titles": [{"bibliographic_title": "Annals of Nuclear Medicine"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The kinetics of Yttrium-90 (Y-90) in bone of mice was investigated in combination with edetate calcium disodium (CaNa2EDTA). One goup of mice were intraperitoneally administered 37.5 mg/kg CaNa2EDTA or 0.9% NaCl as a control at 1,22,34,46,58,70,82,94,154 and 166 h after injection of Y-90 acetate (post-administration), and the biodistributuin was studied at 3,24,72,120 and 168 h postinjection of Y-90 acetate. No difference between the post-CaNa2EDTA-treated mice and the control was demonstrated in the radioactivity in the bone. A decrease in radioactivity in the liver and kidneys was accelerated, and the radioactivity was lower than the control at 120 h postinjection. The other group of mice were also given the same dose of chelator at 12 h and 1 h preinjection of Y-90 acetate and at 1,22,34,46,58,70 82,94,154 and 166 h after injection of Y-90 acetate (pre- and post-administration), the radioactivity in bone at 3 h postinjection was signicicantly lower than in the control (24.4 3.92% ID/g vs. 31.7 2.26% ID/g, p\u003c0.05), but the decrease was not sequential. A significant reduction in radioactivity in the blood, kidneys and liver was demonstrated at 3 h, 72 h and 72 h postinjection. In conclusion, the CaNa2EDTA with the administration achedule employed here cannot chelate the Y-90 from bone but the free Y-90 before deposition into bone.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0914-7187", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Watanabe, Naoyuki"}], "nameIdentifiers": [{"nameIdentifier": "438285", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oriuchi, Noboru"}], "nameIdentifiers": [{"nameIdentifier": "438286", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanada, Shuji"}], "nameIdentifiers": [{"nameIdentifier": "438287", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murata, Hajime"}], "nameIdentifiers": [{"nameIdentifier": "438288", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inoue, Tomio"}], "nameIdentifiers": [{"nameIdentifier": "438289", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki, Yasuhito"}], "nameIdentifiers": [{"nameIdentifier": "438290", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Endou, Keigo"}], "nameIdentifiers": [{"nameIdentifier": "438291", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "et.al"}], "nameIdentifiers": [{"nameIdentifier": "438292", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "渡辺 直行", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "438293", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "棚田 修二", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "438294", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "村田 啓", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "438295", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "井上 登美夫", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "438296", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐々木 康人", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "438297", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "遠藤 啓吾", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "438298", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effect of edetate calcium disodium on yttrium-90 activity in bone of mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Effect of edetate calcium disodium on yttrium-90 activity in bone of mice"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/44088", "pubdate": {"attribute_name": "公開日", "attribute_value": "2006-05-22"}, "publish_date": "2006-05-22", "publish_status": "0", "recid": "44088", "relation": {}, "relation_version_is_last": true, "title": ["Effect of edetate calcium disodium on yttrium-90 activity in bone of mice"], "weko_shared_id": -1}
Effect of edetate calcium disodium on yttrium-90 activity in bone of mice
https://repo.qst.go.jp/records/44088
https://repo.qst.go.jp/records/440885c20c432-5175-4ecc-83e3-3ec5df993e26
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2006-05-22 | |||||
タイトル | ||||||
タイトル | Effect of edetate calcium disodium on yttrium-90 activity in bone of mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Watanabe, Naoyuki
× Watanabe, Naoyuki× Oriuchi, Noboru× Tanada, Shuji× Murata, Hajime× Inoue, Tomio× Sasaki, Yasuhito× Endou, Keigo× et.al× 渡辺 直行× 棚田 修二× 村田 啓× 井上 登美夫× 佐々木 康人× 遠藤 啓吾 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The kinetics of Yttrium-90 (Y-90) in bone of mice was investigated in combination with edetate calcium disodium (CaNa2EDTA). One goup of mice were intraperitoneally administered 37.5 mg/kg CaNa2EDTA or 0.9% NaCl as a control at 1,22,34,46,58,70,82,94,154 and 166 h after injection of Y-90 acetate (post-administration), and the biodistributuin was studied at 3,24,72,120 and 168 h postinjection of Y-90 acetate. No difference between the post-CaNa2EDTA-treated mice and the control was demonstrated in the radioactivity in the bone. A decrease in radioactivity in the liver and kidneys was accelerated, and the radioactivity was lower than the control at 120 h postinjection. The other group of mice were also given the same dose of chelator at 12 h and 1 h preinjection of Y-90 acetate and at 1,22,34,46,58,70 82,94,154 and 166 h after injection of Y-90 acetate (pre- and post-administration), the radioactivity in bone at 3 h postinjection was signicicantly lower than in the control (24.4 3.92% ID/g vs. 31.7 2.26% ID/g, p<0.05), but the decrease was not sequential. A significant reduction in radioactivity in the blood, kidneys and liver was demonstrated at 3 h, 72 h and 72 h postinjection. In conclusion, the CaNa2EDTA with the administration achedule employed here cannot chelate the Y-90 from bone but the free Y-90 before deposition into bone. | |||||
書誌情報 |
Annals of Nuclear Medicine 巻 13, 号 6, p. 397-4000, 発行日 1999-12 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0914-7187 |