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Effect of edetate calcium disodium on yttrium-90 activity in bone of mice
https://repo.qst.go.jp/records/44088
https://repo.qst.go.jp/records/440885c20c432-5175-4ecc-83e3-3ec5df993e26
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-05-22 | |||||
| タイトル | ||||||
| タイトル | Effect of edetate calcium disodium on yttrium-90 activity in bone of mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Watanabe, Naoyuki
× Watanabe, Naoyuki× Oriuchi, Noboru× Tanada, Shuji× Murata, Hajime× Inoue, Tomio× Sasaki, Yasuhito× Endou, Keigo× et.al× 渡辺 直行× 棚田 修二× 村田 啓× 井上 登美夫× 佐々木 康人× 遠藤 啓吾 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The kinetics of Yttrium-90 (Y-90) in bone of mice was investigated in combination with edetate calcium disodium (CaNa2EDTA). One goup of mice were intraperitoneally administered 37.5 mg/kg CaNa2EDTA or 0.9% NaCl as a control at 1,22,34,46,58,70,82,94,154 and 166 h after injection of Y-90 acetate (post-administration), and the biodistributuin was studied at 3,24,72,120 and 168 h postinjection of Y-90 acetate. No difference between the post-CaNa2EDTA-treated mice and the control was demonstrated in the radioactivity in the bone. A decrease in radioactivity in the liver and kidneys was accelerated, and the radioactivity was lower than the control at 120 h postinjection. The other group of mice were also given the same dose of chelator at 12 h and 1 h preinjection of Y-90 acetate and at 1,22,34,46,58,70 82,94,154 and 166 h after injection of Y-90 acetate (pre- and post-administration), the radioactivity in bone at 3 h postinjection was signicicantly lower than in the control (24.4 3.92% ID/g vs. 31.7 2.26% ID/g, p<0.05), but the decrease was not sequential. A significant reduction in radioactivity in the blood, kidneys and liver was demonstrated at 3 h, 72 h and 72 h postinjection. In conclusion, the CaNa2EDTA with the administration achedule employed here cannot chelate the Y-90 from bone but the free Y-90 before deposition into bone. | |||||
| 書誌情報 |
Annals of Nuclear Medicine 巻 13, 号 6, p. 397-4000, 発行日 1999-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-7187 | |||||
