@article{oai:repo.qst.go.jp:00044088,
 author = {Watanabe, Naoyuki and Oriuchi, Noboru and Tanada, Shuji and Murata, Hajime and Inoue, Tomio and Sasaki, Yasuhito and Endou, Keigo and et.al and 渡辺 直行 and 棚田 修二 and 村田 啓 and 井上 登美夫 and 佐々木 康人 and 遠藤 啓吾},
 issue = {6},
 journal = {Annals of Nuclear Medicine},
 month = {Dec},
 note = {The kinetics of Yttrium-90 (Y-90) in bone of mice was investigated in combination with edetate calcium disodium (CaNa2EDTA). One goup of mice were intraperitoneally administered 37.5 mg/kg CaNa2EDTA or 0.9% NaCl as a control at 1,22,34,46,58,70,82,94,154 and 166 h after injection of Y-90 acetate (post-administration), and the biodistributuin was studied at 3,24,72,120 and 168 h postinjection of Y-90 acetate. No difference between the post-CaNa2EDTA-treated mice and the control was demonstrated in the radioactivity in the bone. A decrease in radioactivity in the liver and kidneys was accelerated, and the radioactivity was lower than the control at 120 h postinjection.  The other group of mice were also given the same dose of chelator at 12 h and 1 h preinjection of Y-90 acetate and at 1,22,34,46,58,70 82,94,154 and 166 h after injection of Y-90 acetate (pre- and post-administration), the radioactivity in bone at 3 h postinjection was signicicantly lower than in the control (24.4 3.92% ID/g vs. 31.7 2.26% ID/g, p<0.05), but the decrease was not sequential. A significant reduction in radioactivity in the blood, kidneys and liver was demonstrated at 3 h, 72 h and 72 h postinjection.  In conclusion, the CaNa2EDTA with the administration achedule employed here cannot chelate the Y-90 from bone but the free Y-90 before deposition into bone.},
 pages = {397--4000},
 title = {Effect of edetate calcium disodium on yttrium-90 activity in bone of mice},
 volume = {13},
 year = {1999}
}